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dc.contributor.authorJiao, Yun
dc.contributor.authorMedina Hernández, Loreta Mª
dc.contributor.authorVeenman, C. Leo
dc.contributor.authorToledo, Claudio
dc.contributor.authorPuelles, Luis
dc.contributor.authorReiner, Anton
dc.description.abstractIn mammals, the subthalamic nucleus (STN) is a glutamatergic diencephalic cell group that develops in the caudal hypothalamus and migrates to a position above the cerebral peduncle. By its input from the external pallidal segment and projection to the internal pallidal segment, STN plays a critical role in basal ganglia functions. Although the basal ganglia in birds is well developed, possesses the same major neuron types as in mammals, and plays a role in movement control similar to that in mammals, it has been uncertain whether birds possess an STN. We report here evidence indicating that the so-called anterior nucleus of the ansa lenticularis (ALa) is the avian homolog of mammalian STN. First, the avian ALa too develops within the mammillary hypothalamic area and migrates to a position adjacent to the cerebral peduncle. Second, ALa specifically receives input from dorsal pallidal neurons that receive input from enkephalinergic striatal neurons, as is true of STN. Third, ALa projects back to avian dorsal pallidum, as also the case for STN in mammals. Fourth, the neurons of ALa contain glutamate, and the target neurons of ALa in dorsal pallidum possess AMPA-type glutamate receptor profiles resembling those of mammalian pallidal neurons. Fifth, unilateral lesions of ALa yield behavioral disturbances and movement asymmetries resembling those observed in mammals after STN lesions. These various findings indicate that ALa is the avian STN, and they suggest that the output circuitry of the basal ganglia for motor control is similar in birds and mammals.
dc.publisherSociety for Neuroscience
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofJournal of Neuroscience, 2000, vol. 20, núm. 18, p. 6998-7010
dc.rightscc-by-nc-sa (c) Jiao, Yun et al., 2000
dc.subjectMotor functions
dc.subjectSegmental development
dc.titleIdentification of the anterior nucleus of the ansa lenticularis in birds as the homologue of the mammalian subthalamic nucleus

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cc-by-nc-sa (c) Jiao, Yun et al., 2000
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