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dc.contributor.authorSoler, Cassandra
dc.contributor.authorGoossens, Tim
dc.contributor.authorBermejo, Alvaro
dc.contributor.authorMigura-García, Lourdes
dc.contributor.authorCusco, Anna
dc.contributor.authorFrancino, Olga
dc.contributor.authorFraile Sauce, Lorenzo José
dc.date.accessioned2019-04-01T10:40:20Z
dc.date.available2019-04-01T10:40:20Z
dc.date.issued2018
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/66114
dc.description.abstractAntimicrobials have been used in a prophylactic way to decrease the incidence of digestive disorders during the piglet post-weaning period. Nowadays, it is urgent to reduce their consumption in livestock to address the problem of antimicrobial resistance. In this study, the effect of a product on piglet microbiota has been investigated as an alternative to antimicrobials. Three groups of ten post-weaning pigs were sampled at 0, 15 and 30 days one week post-weaning; the control, antibiotic and feed additive group received a standard post-weaning diet without antibiotics or additives, the same diet as the control group but with amoxicillin and colistin sulphate and the same diet as the control group but with a feed additive (Sanacore-EN, Nutriad International N.V.), respectively. The total DNA extracted from faeces was used to amplify the 16S RNA gene for massive sequencing under manufacturer's conditions. Sequencing data was quality filtered and analyzed using QIIME software and suitable statistical methods. In general terms, age modifies significantly the microbiota of the piglets. Thus, the oldest the animal, the highest bacterial diversity observed for the control and the feed additive groups. However, this diversity was very similar in the antibiotic group throughout the trial. Interestingly, a clear increase in abundance of Bacillus and Lactobacillus spp was detected within the feed additive group versus the antibiotic and control groups. In conclusion, the feed additive group had a positive effect in the endogenous microbiota of post-weaning pigs increasing both, the diversity of bacterial families and the abundance of lactic acid bacteria during the post-weaning period.ca_ES
dc.description.sponsorshipThis work was supported by a research contract of the University of Lleida with Nutriad International N.V. The funder provided support in the form of salaries for authors [Tim Goosens and Alvaro Bermejo], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the "author contributions" section.ca_ES
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0197353ca_ES
dc.relation.ispartofPLoS ONE, 2018, vol.13, núm.5, e0197353ca_ES
dc.rightscc-by, (c) Soler et al., 2018ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDigestive microbiota is different in pigs receiving antimicrobials or a feed additive during the nursery periodca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec027001
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0197353


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cc-by, (c) Soler et al., 2018
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