A monographic study of the caskets of Saints Adrian and Natalia from The Art Institute of Chicago was carried out. Historiography of Romanesque art has forgotten this piece, but it was studied analyzing the life cycle of both Eastern Saints, examining its technical aspects as well as its epigraphs. All is kept in the study limits of the origin of its worship in Byzantium, the transfer of their relics to Rome and during the 9th and 10th centuries, its spread in the old Astur-Leonese Kingdom. Finally, we studied the iconography in relation to the Passio written about the martyr and a comparison is carried out with the silversmith works in San Isidoro de Leon.