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dc.contributor.authorFernández Armenteros, José Manuel
dc.contributor.authorGómez Arbonés, Javier
dc.contributor.authorButi, Miquel
dc.contributor.authorBetriu i Bars, M. Àngels
dc.contributor.authorSanmartín Novell, Verònica
dc.contributor.authorOrtega Bravo, Marta
dc.contributor.authorMartínez Alonso, Montserrat
dc.contributor.authorGarí Marsol, Eloi
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorSantamaria-Babi, L.
dc.contributor.authorCasanova i Seuma, Josep M. (Josep Manel)
dc.date.accessioned2019-03-11T09:02:29Z
dc.date.available2020-08-28T22:21:57Z
dc.date.issued2019
dc.identifier.issn0926-9959
dc.identifier.urihttp://hdl.handle.net/10459.1/65926
dc.description.abstractAbstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and traditional cardiovascular risk factors. Objective: Identify classic cardiovascular risk factors and metabolic syndrome (MS) in patients with psoriasis, their possible association with its severity and compare it with the non-psoriatic population. Methods: This is an observational and cross-sectional population study in Lleida (Spain) from a joint hospital / primary care database. Results: The database comprised 398,701 individuals. There were 6,868 cases registered as psoriasis (1.7%), and 499 of them (7.3%) were classified as moderate-severe psoriasis. Patients with psoriasis had a higher prevalence of traditional cardiovascular risk factors than non-psoriatic population: diabetes mellitus 2 (13.9% vs 7.4%, OR 2.01), dyslipidemia (28.8% vs 17.4%, OR 1.92), arterial hypertension (31.2% vs 19.0%, OR 1.93), obesity (33.7% vs 28.1%, OR 1.30), altered fasting basal glycaemia (21.4% vs 15.1%, OR 1.54), low cholesterol-HDL (38.1% vs 32.3%, OR 1.29), hypertriglyceridemia (45.7% vs 35.2%, OR 1.55) and high waist circumference (75.7% vs 72.3%, OR 1.19). MS was more prevalent in psoriatic patients (28.3% vs 15.1%, OR 2.21) and cardiovascular risk factors were similar between psoriasis severity groups. Psoriatic patients had a higher prevalence of ischemic heart disease (3.3% vs 1.8%, OR 1.87) and vascular-cerebral accidents (1.8% vs 1.2%, OR 1.55). A model for MS showed a significant non-linear relationship with age and sex, and significant differences between patients with and without psoriasis. Conclusion: We found statistically differences in relation to the prevalence of cardiovascular risk factors, MS and major cardiovascular events in psoriatic patients. However, differences were not seen between psoriasis severity groups. Our work reinforces the need for a multidisciplinary approach and close monitoring of cardiovascular risk factors in these patients to prevent a cardiovascular event.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1111/jdv.15159
dc.relation.ispartofJournal of the European Academy of Dermatology and Venereology, 2019, vol. 33, núm. 1, p. 128-135
dc.rights(c) European Academy of Dermatology and Venereology, 2018
dc.subjectPsoriasis
dc.subjectEpidemiology
dc.subjectMetabolic syndrome
dc.subjectCardiovascular risk factors
dc.titlePsoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
dc.title.alternativePsoriasis and cardiovascular risk factors
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2019-03-11T09:02:29Z
dc.identifier.idgrec027663
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1111/jdv.15159


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