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dc.contributor.authorPérez Fusté, Noel
dc.contributor.authorGuasch Vallés, Marta
dc.contributor.authorGuillén, Pere
dc.contributor.authorAnerillas, Carlos
dc.contributor.authorCemeli, Tània
dc.contributor.authorPedraza González, Neus
dc.contributor.authorFerrezuelo, Francisco
dc.contributor.authorEncinas Martín, Mario
dc.contributor.authorMoralejo Vidal, Mª Angeles
dc.contributor.authorGarí Marsol, Eloi
dc.date.accessioned2019-03-11T08:29:48Z
dc.date.available2019-03-11T08:29:48Z
dc.date.issued2019
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10459.1/65923
dc.description.abstractβ-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. Unexpectedly, we have observed that this compound promoted a short-transitory proliferation arrest at 24 h after its addition on the medium. We have determined that this transitory arrest was dependent on the cell-cycle regulator protein Retinoblastoma. Moreover, dermal fibroblasts increase their migration capacities at 24 h after barley β-glucan addition. Also, we have described that barley β-glucan strongly reduced the ability of fibroblasts to attach and to spread on cell plates. Our data indicates that barley β-glucan signal induces an early response in HDF cells favoring migration versus proliferation. This feature is consistent with our observation that the topical addition of our barley β-glucan in vivo accelerates the wound closure in mouse skin.ca_ES
dc.description.sponsorshipThis work was funded by projects AGL2015-69435-C3-1-R and BFU2016-78826-P from the Ministerio de Economía y Competitividad. T. Cemeli (FPU13/06590) was supported by a predoctoral fellowship from Ministerio de Educación, Cultura y Deportes. M. Guasch was supported by a predoctoral fellowship from UdL.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationMINECO/PN2013-2016/AGL2015-69435-C3-1-R
dc.relationMINECO/PN2013-2016/BFU2016-78826-P
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.carbpol.2019.01.090ca_ES
dc.relation.ispartofCarbohydrate Polymers, 2019, vol. 210, p. 389-398ca_ES
dc.rightscc-by-nc-nd (c) Elsevier, 2019ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBarley β-glucanca_ES
dc.subjectRetinoblastomaca_ES
dc.subjectProliferation arrestca_ES
dc.subjectMigrationca_ES
dc.titleBarley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblastsca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec028269
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2019.01.090


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cc-by-nc-nd (c) Elsevier, 2019
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Elsevier, 2019