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dc.contributor.authorJové Font, Mariona
dc.contributor.authorPradas Barriga, Irene
dc.contributor.authorDominguez Gonzalez, Mayelin
dc.contributor.authorFerrer, Isidre
dc.contributor.authorPamplona Gras, Reinald
dc.description.abstractThe human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions are unknown. In this review, we focus attention on the role of lipids and the importance of the cross-regionally different vulnerabilities in human brain aging. In particular, we first consider a brief approach to the lipidomics of human brain, the relationship between lipids and lipoxidative damage, the role of lipids in human brain aging, and the specific targets of lipoxidative damage in human brain and during aging. It is proposed that the restricted set of modified proteins and the functional categories involved may be considered putative collaborative factors contributing to neuronal aging, and that mitochondrial ATP synthase is a key lipoxidative target in human brain aging.ca_ES
dc.description.sponsorshipResearch by the authors was supported by the Spanish Ministry of Economy and Competitiveness (Institute of Health Carlos III, Spain, FIS grants PI14/00757 and PI14/00328PI14/00328), and the Autonomous Government of Catalonia (Catalonia, Spain, 2017SGR696) to I.F. and R.P. This study was co-financed by FEDER funds from the European Union (‘A way to build Europe’).ca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofRedox Biology, 2019, vol. 23, p. 101082ca_ES
dc.rightscc-by-nc-nd (c) Mariona Jové et al., 2018ca_ES
dc.subjectAdvanced lipoxidation end productsca_ES
dc.titleLipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation targetca_ES

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cc-by-nc-nd (c) Mariona Jové et al., 2018
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Mariona Jové et al., 2018