Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

View/ Open
Issue date
2019Author
Martín Garí, Meritxell
Sánchez, V.
Riart Solans, M.
Ludwig, Iziar A.
Suggested citation
Granado-Serrano, Ana Belén;
Martín Garí, Meritxell;
Sánchez, V.;
Riart Solans, M.;
Berdún Hernández, Rebeca;
Ludwig, Iziar A.;
...
Serrano Casasola, José Carlos Enrique.
(2019)
.
Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia.
Scientific Reports, 2019, vol. 9, núm. 1772, p. 1-13.
https://doi.org/10.1038/s41598-019-38874-3.
Metadata
Show full item recordAbstract
Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of hypercholesterolemic subjects. Microbiota composition, SCFAs, BA and blood lipid profile from male volunteers with hypercholesterolemia (HC) and normocholesterolemia (NC) were determined by 16S rDNA sequencing, HPLC, GC and NMR, respectively. HC subjects were characterized by having lower relative abundance of Anaeroplasma (0.002% vs 0.219%, p-value = 0.026) and Haemophilus (0.041% vs 0.078%, p-value = 0.049), and higher of Odoribacter (0.51% vs 0.16%; p-value = 0.044). Correlation analysis revealed that Anaeroplasma and Haemophilus were associated to an unfavourable lipid profile: they correlated negatively to cholesterol and triglycerides related biomarkers and the ratio total to high density lipoprotein (HDL) cholesterol, and positively to HDL size. Odoribacter displayed an opposite behaviour. Faecal SCFAs profile revealed higher abundance of isobutyric (2.76% vs 0.82%, p-value = 0.049) and isovaleric acid (1.32% vs 0.06%, p-value = 0.016) in HC. Isobutyric acid correlated positively with Odoribacter and lipid parameters indicative of an unfavourable profile. BA profile did not show differences between groups. It was concluded that HC subjects showed a particular faecal bacterial signature and SCFAs profile associated with their lipid profile.
Is part of
Scientific Reports, 2019, vol. 9, núm. 1772, p. 1-13European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Granado-Serrano, Ana Belén et al., 2019
Related items
Showing items related by title, author, creator and subject.
-
Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study
Calderón-Pérez, Lorena; Gosalbes, Maria José; Yuste, Silvia; Valls, Rosa M.; Pedret, Anna; Llauradó, Elisabet; Jimenez-Hernandez, Núria; Artacho, Alejandro; Pla-Pagà, Laura; Companys, Judit; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Rubió Piqué, Laura; Solà, Rosa (Springer Nature, 2020-04-15)Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive ... -
Effect of dietary bioactive compounds on mitochondrial and metabolic flexibility
Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Martín-Gari, Meritxell; Granado-Serrano, Ana Belén; Portero Otín, Manuel (MDPI, 2016-03)Metabolic flexibility is the capacity of an organism to adequately respond to changes in the environment, such as nutritional input, energetic demand, etc. An important player in the capacity of adaptation through different ... -
Characterization of the post-prandial insulinemic response and low glycaemic index of a soy beverage
Serrano Casasola, José Carlos Enrique; Martín Garí, Meritxell; Cassanyé, Anna; Granado-Serrano, Ana Belén; Portero Otín, Manuel (Public Library of Science, 2017)Soybean is recognized as rich source of bioactive compounds for the improvement of glucose homeostasis. However, the post-prandial mechanisms of action have not been extensively described. The aim of this study is to ...