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dc.contributor.authorYuste, Silvia
dc.contributor.authorLudwig, Iziar A.
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorRomero Fabregat, Mª Paz
dc.contributor.authorPedret, Anna
dc.contributor.authorValls, Rosa M.
dc.contributor.authorSolà, Rosa
dc.contributor.authorMotilva Casado, Mª José
dc.contributor.authorMacià i Puig, Ma Alba
dc.description.abstractThe aim of this study was to investigate comprehensively the metabolic pathways and human bioavailability of anthocyanins and other phenolic compounds in apple matrix, and to elucidate potential intake biomarkers. After the acute intake of a red-fleshed apple snack, plasma and urine were collected and analyzed by UPLC-MS/MS. A total of 37 phase-II and microbial phenolic metabolites were detected in plasma and urine. Among these, phloretin glucuronide, cyanidin-3-O-galactoside (plasma and urine) and peonidin-3-O galactoside (urine) were the only metabolites detected in all the volunteers and not detected at basal conditions. The maximum urine excretion was detected at 2-4 h, and the main increase in plasma of phloretin glucuronide and cyanidin-3-O-galactoside was observed at 2h post-intake (61.0  6.82 and 10.3  1.50 nM, respectively). These metabolites could be selected as the best intake biomarkers of red-fleshed apple that might be useful in human intervention studies when studying the bioactivity of red-fleshed apple.ca_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Industry, Economy and Competitiveness through the AGL2016-76943-C2-1-R and AGL2016-76943-C2- 2-R projects (co-funded by the European Social Fund, European Union); I.A.L. enjoys a post-doctoral contract (2017PMF-POST2-19) from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV). S.Y. was supported by a grant from the University of Lleida. In addition, the authors are grateful to NUFRI SAT (Mollerussa, Lleida, Catalonia, Spain) for providing the red-fleshed apples. A.P. has Torres Quevedo contract (Subprograma Estatal de Incorporación, Plan Estatal de Investigación Científica y Técnica y de Innovación). NFOC-Salut group is a consolidated research group of Generalitat de Catalunya, Spain (2017 SGR522).ca_ES
dc.relation.isformatofVersió postprint del document publicat a
dc.relation.ispartofJournal of Functional Foods, 2019, vol. 55, p. 146-155ca_ES
dc.rightscc-by-nc-nd (c) Elsevier, 2019ca_ES
dc.subjectMetabolic pathwaysca_ES
dc.subjectPhenolic compoundsca_ES
dc.subjectRed-fleshed appleca_ES
dc.titleIn vivo biotransformation of (poly)phenols and anthocyanins of red-fleshed apple and identification of intake biomarkersca_ES

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cc-by-nc-nd (c) Elsevier, 2019
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Elsevier, 2019