Treatment strategies after acute exacerbations of chronic obstructive pulmonary disease: Impact on mortality
Casas-Méndez, Luis Fernando
Abadías, María José
Bardés Robles, Ignasi
Batlle Garcia, Jordi de
MetadataShow full item record
Introduction Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common reason for presentation to emergency departments (ED), but the management of these episodes is often heterogeneous regardless of their potential impact on short-term adverse outcomes. Methods This was a longitudinal, retrospective study of all patients>40 years old admitted to the ED of two Spanish teaching hospitals for an AECOPD between January 1st and May 31st, 2016. All data were collected from electronic medical records. The primary outcomes were patient treatment at discharge and 90-day mortality. Logistic regression was used to model the determinants of 90-day mortality. Results Of the 465 included patients, 56% were prescribed a 3-drug combination at hospital discharge, 22% a 2-drug combination, 19% a single drug, and 4% other or no treatment. Approximately 8% of patients died within 90 days after an AECOPD. Multivariate logistic models revealed that having more than 2 severe exacerbations within the last 12 months (OR (95% CI): 15.12 (4.22–54.22)) and being prescribed a single drug at discharge (OR (95% CI): 7.23 (2.44– 21.38)) were the main determinants of 90-day mortality after an AECOPD. Conclusions This study reflects the real-life heterogeneity in the pharmacological treatments prescribed after an ED admission for an AECOPD and suggests the potential impact of suboptimal inhaled treatment strategies on 90-day mortality rates.
Is part ofPLoS ONE, vol. 13, núm. 12, e0208847
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Fernando Casas et al., 2018
Showing items related by title, author, creator and subject.
Exacerbations of chronic obstructive pulmonary disease: An analysis of the care process in a regional hospital emergency department Abadías, María José; Yuguero Torres, Oriol; Bardés Robles, Ignasi; Casas-Méndez, Luis Fernando; Barbé Illa, Ferran; Batlle Garcia, Jordi de (Wolters Kluwer Health, Inc, 2018)To describe the characteristics of patients visiting a Hospital Emergency Department (HED) due to chronic obstructive pulmonary disease (COPD) exacerbation (AECOPD) and to evaluate their management. A cross-sectional ...
Risk of exacerbation in chronic obstructive pulmonary disease: a primary care retrospective cohort study Montserrat i Capdevila, Josep; Godoy i García, Pere; Marsal Mora, Josep Ramon; Barbé Illa, Ferran; Galván, Leonardo (BioMed Central, 2015)Background: The risk of exacerbation in chronic obstructive pulmonary disease (COPD) depends on the severity of disease and other less well known factors. Predictive models of exacerbation are more accurate than the forced ...
Clinico-epidemiological characteristics of men and women with a new diagnosis of chronic obstructive pulmonary disease: a database (SIDIAP) study Montserrat i Capdevila, Josep; Marsal Mora, Josep Ramon; Ortega Bravo, Marta; Castañ, Maria Teresa; Alsedà Graells, Miquel; Barbé Illa, Ferran; Godoy i García, Pere (BioMed Central, 2021-01-28)Background: The risk of developing Chronic Obstructive Pulmonary Disease (COPD), the associated comorbidities and response to bronchodilators might differ in men and women. The objective of this study was to determine the ...