Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia

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2018
Author
Holubiec, Mariana Inés
Romero, Juan I.
Suárez, Juan
Portavella, Manuel
Fernández Espejo, Emilio
Blanco Calvo, Eduardo
Galeano, Pablo
Rodríguez de Fonseca, Fernando
Suggested citation
Holubiec, Mariana Inés; Romero, Juan I.; Suárez, Juan; Portavella, Manuel; Fernández Espejo, Emilio; Blanco Calvo, Eduardo; ... Rodríguez de Fonseca, Fernando. (2018) . Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia. Psychopharmacology, 2018, vol. 235, núm. 10, p. 2929–2945. https://doi.org/10.1007/s00213-018-4982-9.
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Abstract
Neonatal anoxia-ischemia (AI) particularly affects the central nervous system. Despite the many treatments that have been tested, none of them has proven to be completely successful. Palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are acylethanolamides that do not bind to CB1 or CB2 receptors and thus they do not present cannabinoid activity. These molecules are agonist compounds of peroxisome proliferator-activator receptor alpha (PPARα), which modulates the expression of different genes that are related to glucose and lipid metabolism, inflammation, differentiation and proliferation.
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http://hdl.handle.net/10459.1/65513
DOI
https://doi.org/10.1007/s00213-018-4982-9
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Psychopharmacology, 2018, vol. 235, núm. 10, p. 2929–2945
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