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dc.contributor.authorGómez Rioja, Rubén
dc.contributor.authorMartínez Espartosa, Débora
dc.contributor.authorSegovia, Marta
dc.contributor.authorIbarz Escuer, Mercedes
dc.contributor.authorLlopis, María Antonia
dc.contributor.authorBauçà, Josep Miquel
dc.contributor.authorMarzana, Itziar
dc.contributor.authorBarba, Nuria
dc.contributor.authorVentura, Monserrat
dc.contributor.authorGarcía del Pino, Isabel
dc.contributor.authorPuente, Juan José
dc.contributor.authorCaballero, Andrea
dc.contributor.authorGómez, Carolina
dc.contributor.authorGarcía Álvarez, Ana
dc.contributor.authorAlsina, María Jesús
dc.contributor.authorÁlvarez, Virtudes
dc.date.accessioned2018-12-20T09:04:10Z
dc.date.available2019-05-05T22:10:25Z
dc.date.issued2018-05-05
dc.identifier.issn1434-6621
dc.identifier.urihttp://hdl.handle.net/10459.1/65373
dc.description.abstractBackground: The stability limit of an analyte in a biological sample can be defined as the time required until a measured property acquires a bias higher than a defined specification. Many studies assessing stability and presenting recommendations of stability limits are available, but differences among them are frequent. The aim of this study was to classify and to grade a set of bibliographic studies on the stability of five common blood measurands and subsequently generate a consensus stability function. Methods: First, a bibliographic search was made for stability studies for five analytes in blood: alanine aminotransferase (ALT), glucose, phosphorus, potassium and prostate specific antigen (PSA). The quality of every study was evaluated using an in-house grading tool. Second, the different conditions of stability were uniformly defined and the percent deviation (PD%) over time for each analyte and condition were scattered while unifying studies with similar conditions. Results: From the 37 articles considered as valid, up to 130 experiments were evaluated and 629 PD% data were included (106 for ALT, 180 for glucose, 113 for phosphorus, 145 for potassium and 85 for PSA). Consensus stability equations were established for glucose, potassium, phosphorus and PSA, but not for ALT. Conclusions: Time is the main variable affecting stability in medical laboratory samples. Bibliographic studies differ in recommedations of stability limits mainly because of different specifications for maximum allowable error. Definition of a consensus stability function in specific conditions can help laboratories define stability limits using their own quality specifications.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1515/cclm-2017-1189
dc.relation.ispartofClinical Chemistry and Laboratory Medicine, 2018, vol. 56, num. 11, p. 1806-1818
dc.subject.classificationAnàlisi de sang
dc.subject.otherAnalysis of blood
dc.titleLaboratory sample stability. Is it possible to define a consensus stability function? An example of five blood magnitudes
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-12-20T09:04:10Z
dc.identifier.idgrec027083
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1515/cclm-2017-1189


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