A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs
Rothschild, Max Frederick
MetadataShow full item record
Arachidonic acid (C20:4) is related to a wide range of biological effects including lipid homeostasis. The fatty acid desaturase-2 (FADS2) gene encodes for the delta-6-desaturase, which is involved in the biosynthesis of C20:4 from linoleic acid (C18:2). The purpose of this study was to characterise mutations in the promoter of the porcine FADS2, evaluating in particular the effect of one haplotype tagging polymorphism (rs321384923A > G) on the biosynthesis pathway of C20:4. A total of 1,192 Duroc barrows with records on fatty acid composition in muscle and subcutaneous fat were genotyped. Pigs carrying the A allele showed, irrespective of fat content, both enhanced FADS2 expression and higher C20:4 in muscle and exhibited increased ratios of C20:4 to C18:2 and of C20:4 to eicosadienoic acid (C20:2) in both muscle and adipose tissue. Despite the inverse relationship observed between C20:4 and fat content, the rs321384923 polymorphism had no impact on lean weight. It is concluded that the haplotype encompassing the rs321384923 polymorphism at the porcine FADS2 affects the n-6 fatty acid profile by specifically modifying the desaturation efficiency of C18:2 to C20:4 rather than by concomitant variations in C18:2 following changes in fat content.
Is part ofScientific Reports, 2018, p. vol. 8, núm. 14336, p.1-9
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
A polymorphism in the stearoyl-CoA desaturase gene promoter increases monounsaturated fatty acid content in dry-cured ham Henriquez Rodriguez, Eliana; Tor i Naudí, Marc; Pena i Subirà, Ramona Natacha; Estany Illa, Joan (Elsevier, 2015)Data on 125 dry-cured hams from purebred Duroc pigs were used to examine whether the favorable effect of the T allele in the promoter region of the stearoyl-CoA desaturase gene (AY487830:g.2228T>C) on monounsaturated fatty ...
A polymorphism in the stearoyl-CoA desaturase gene promoter influences monounsaturated fatty acid content of Duroc × Iberian hams Henriquez Rodriguez, Eliana; Tor i Naudí, Marc; Pena i Subirà, Ramona Natacha; Estany Illa, Joan (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 2015)Data on 74 dry-cured hams from Duroc × Iberian pigs were used to examine whether the tag polymorphism AY487830:g.2228T>C in the promoter region of the stearoyl-CoA desaturase [SCD] gene affect fat desaturation and ...
Genome-Wide Association Study Singles Out SCD and LEPR as the Two Main Loci Influencing Intramuscular Fat Content and Fatty Acid Composition in Duroc Pigs Ros Freixedes, Roger; Gol, Sofia; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Ibañez Escriche, Noelia; Dekkers, Jack C. M.; Estany Illa, Joan (Public Library of Science, 2016)Intramuscular fat (IMF) content and fatty acid composition affect the organoleptic quality and nutritional value of pork. A genome-wide association study was performed on 138 Duroc pigs genotyped with a 60k SNP chip to ...