Location-dependent effects of trauma on oxidative stress in humans
MetadataShow full item record
Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. For this reason, we evaluated the relationship between the anatomical location of
trauma and plasma total antioxidant capacity (TAC) in a prospective study, where the anatomical locations of trauma in polytraumatic patients (n = 66) were categorized as primary affecting the brain -traumatic brain injury (TBI)-, thorax, abdomen and pelvis or extremities. We measured the following: plasma TAC by 2 independent methods, the contribution of selected antioxidant molecules (uric acid, bilirubin and albumin) to these values and changes after 1 week of progression. Surprisingly, TBI lowered TAC (919 ±335μM Trolox equivalents (TE)) in comparison with other groups (thoracic trauma 1187± 270μM TE; extremities 1025±276μM TE; p = 0.004). The latter 2 presented higher hypoxia (PaO2/FiO2 272±87 mmHg) and hemodynamic instability (inotrope use required in 54.5%) as well. Temporal changes in TAC are also dependent on anatomical location, as thoracic and extremity trauma patients’ TAC values decreased (1187±270 to 1045±263μM TE; 1025±276 to 918±331μM TE) after 1 week (p<0.01), while in TBI these values increased (919±335 to 961±465μM TE). Our results show that the response of plasma antioxidant capacity in trauma patients is strongly dependent on time after trauma and location, with TBI failing to induce such a response.
Is part ofPlos One, 2018, vol. 13, núm 10, e0205519
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Luis Servia et al., 2018
Showing items related by title, author, creator and subject.
Plasma antioxidant capacity in critical polytraumatized patients?: methods, severity, and anatomic location Servià Goixart, Lluís; Trujillano Cabello, Javier; Serrano Casasola, José Carlos Enrique; Pamplona Gras, Reinald; Badia Castello, Mariona; Jové Font, Mariona; Justes, Margarida; Domingo, Joana; Portero Otín, Manuel (BioMed Central, 2014)
A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma Servià Goixart, Lluís; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (BMC (part of Springer Nature), 2019-05-22)Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ...
Classification of dermatological disorders in critical care patients: a prospective observational study Badia Castello, Mariona; Servià Goixart, Lluís; Casanova i Seuma, Josep M. (Josep Manel); Montserrat, Neus; Vilanova, Judit; Vicario, Esther; Rodriguez, Angel; Trujillano Cabello, Javier (Elsevier, 2013)Purpose: The objective of this study was to identify dermatological disorders detected in the intensive care unit (ICU), to analyze their specific characteristics, and to define a useful classification for intensive care ...