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dc.contributor.authorTorres, F.
dc.contributor.authorSantamaria, R.
dc.contributor.authorJimenez, M.
dc.contributor.authorMenjón, R.
dc.contributor.authorIbanez, A.
dc.contributor.authorCollell, M.
dc.contributor.authorAzlor, O.
dc.contributor.authorFraile Sauce, Lorenzo José
dc.date.accessioned2018-10-24T08:42:03Z
dc.date.available2018-10-24T08:42:03Z
dc.date.issued2016
dc.identifier.issn0140-7783
dc.identifier.urihttp://hdl.handle.net/10459.1/64964
dc.descriptionShort Communication
dc.description.abstractThe penetration of antimicrobials in pig tonsils is hardly known. The objective of the study was to quantify the tildipirosin (TD) penetration in tonsils. Animals were randomly divided into six groups (control, T1, T2 (1), T2(5), T2(10), and T2(15)) of eight animals. T1 and T2 groups received a dose of 2 and 4 mg of TD/kg bw in one shot (Zuprevo® MSD Animal Health), respectively, and the control group received 2 mL of saline solution. The animals were sacrificed by intravenous administration of pentobarbital sodium 24 h after finishing the treatment for the control, T1, and T2(1) groups, whereas animals of T2(5), T2(10), and T2(15) groups were sacrificed at 5, 10, and 15 days, post-treatment, respectively. Tonsils and blood samples were taken at necropsy to obtain plasma, and the tildipirosin concentration was determined by high-performance liquid chromatography with tandem mass spectrometry detection. The concentration in plasma was always significantly lower than in tonsil. Average TD tonsil concentrations increased significantly in a dose-dependent manner, and the tonsil TD vs. plasma TD concentration ratio was approximately 75 for the doses of 2 and 4 mg of TD/kg bw at 24 h post-treatment. Moreover, the maximum concentration of tildipirosin in tonsil was observed at 1 day postadministration, and this concentration decreased gradually from this day until 15 days postadministration for the dose of 4 mg of TD/kg bw. Finally, the ratio AUCtonsil/AUCplasma was 97.9, and the T1/2 (h) was clearly higher in tonsil than in plasma.
dc.description.sponsorshipThe study was funded by MSD Animal Health.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherJohn Wiley & Sons Ltd
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1111/jvp.12258
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics, 2016, num. 39, p. 199-201
dc.rights(c) John Wiley & Sons Ltd, 2015
dc.titlePharmacokinetics of tildipirosin in pig tonsils
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-10-24T08:42:08Z
dc.identifier.idgrec023038
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1111/jvp.12258


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