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dc.contributor.authorLinko, Anna-Maria
dc.contributor.authorRoss, Alastair B.
dc.contributor.authorKamal-Eldin, Afaf
dc.contributor.authorSerena, Anja
dc.contributor.authorBjørnbak Kjær, Anna Kirstin
dc.contributor.authorJørgensen, Henry
dc.contributor.authorPeñalvo, José L.
dc.contributor.authorAdlercreutz, Herman
dc.contributor.authorAman, Per
dc.contributor.authorBach Knudsen, Knud Erik
dc.date.accessioned2018-10-17T08:24:01Z
dc.date.available2018-10-17T08:24:01Z
dc.date.issued2006
dc.identifier.issn0007-1145
dc.identifier.urihttp://hdl.handle.net/10459.1/64898
dc.description.abstractAlkylresorcinols (AR) are phenolic lipids found in high amounts in wholegrain wheat and rye. They may be important as bioactive components and/or biomarkers of wholegrain wheat and rye intake. AR absorption was studied with pigs during a habitual diet and after a single meal of ARrich diet. In study 1, four pigs were fed wholegrain rye (RD) and white wheat bread (WD) for 1 week in a cross-over design. Arterial and venous AR concentrations were determined over 540 min after feeding on days 5 and 7. In study 2, four pigs were fed a synthetic, starch-based diet for 5 d, and arterial and venous AR concentrations were determined over 960 min after feeding a single meal of RD. In study 1, plasma AR concentrations after consuming RD peaked at 120 min, remained elevated between 120 and 420 min, and were re-elevated on refeeding at 480 min. In study 2, AR appeared in the plasma after 60 min, peaked at 180–240 min, and remained elevated after 960 min. The apparent elimination half-life was 3·93 h, and the maximum plasma concentration was 666 (SEM 35) nmol/l. Arterial and venous plasma AR concentrations were similar, suggesting that AR are absorbed via the lymphatic system. AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5 d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake.ca_ES
dc.description.sponsorshipThe present study was supported by the Nordic Industrial Fund; the Danish Agricultural and Veterinary Research Council; Cerealia AB, Sweden; Wasabro¨d AB, Sweden; Vaasan & Vaasan, Finland; Fazer Oululainen, Finland. A.-M. L. was supported by the Sigrid Juse´lius Foundation, Helsinki, Finland and Finska La¨karesa¨llskapet, Helsinki, Finland.ca_ES
dc.language.isoengca_ES
dc.publisherCambridge University Pressca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1079/BJN20051642ca_ES
dc.relation.ispartofBritish Journal of Nutrition, 2006, vol. 95, p. 282-287ca_ES
dc.rights(c) Cambridge University Press, 2006ca_ES
dc.subjectAlkylresorcinolsca_ES
dc.subjectBiomarkersca_ES
dc.subjectWholegrain cerealca_ES
dc.subjectRyeca_ES
dc.titleKinetics of the appearance of cereal alkylresorcinols in pig plasmaca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec010561
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1079/BJN20051642


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