Show simple item record

dc.contributor.authorMartin-Orúe, S. M.
dc.contributor.authorBalcells Terés, Joaquim
dc.contributor.authorGuada, J. A.
dc.contributor.authorCastrillo, C.
dc.date.accessioned2018-10-17T07:28:34Z
dc.date.available2018-10-17T07:28:34Z
dc.date.issued1995
dc.identifier.issn0007-1145
dc.identifier.urihttp://hdl.handle.net/10459.1/64892
dc.description.abstractThe present experiment was camed out to study the endogenous losses of purine and pyrimidine derivatives from pregnant sows. Three pregnant and three non-pregnant Large White x Landrace sows were fed on a purine-free diet composed of starch, glucose, sucrose and vegetable oil, with casein as the protein source. The experiment began, for the six animals, after diagnosis of pregnancy and was divided into six 12 d periods. Urine was collected during the Arst 3 d of each experimental period by means of a urethral catheter for determination of allantoin, uric acid, xanthine, hypoxanthine and pseudouridine concentrations. In the absence of dietary nucleic acids (NA), allantoin and, as a consequence, excretion of total purine derivatives (PD) decreased significantly to a constant value (128.3 (SE 7.07) ,umol/kg metabolic live weight (W"75) per d), an amount assumed to represent endogenous excretion. Excretion of uric acid (38.7 (SE 2-15) mollkg W0'p7e5r d), hypoxanthine (21.0 (SE 2.58) ymollkg W'75 per d) and xanthine (11-2 (SE 0.83) pmol/kg W@" per d) were not affected by the experimental treatment, although there was a significant decrease in hypoxanthine excretion in pregnant sows (from 25.5 to 5.2 pnol/kg W@75 per d) compared with nowpregnant sows (from 26.7 to 44%/rmol/kg W@75p er d). Creatinine excretion was not affected by pregnancy and was used as an internal urinary marker. Purine excretion, either expressed as pmol/kg WoT5 per d or as the ratio PD:creatinine, was not affected by experimental treatment, although an apparent increase in pseudouridine excretion, a modified unsalvageable catabolite of RNA-pyrimidine, was found in late pregnancy (3.6 v. 5.2 mo1/100 mol creatinine in non-pregnant sows compared with pregnant sows at 102 d collection).ca_ES
dc.description.sponsorshipThis work has been supported by the CICYT Project Gan 91-1050-C02-01ca_ES
dc.language.isoengca_ES
dc.publisherCambridge University Pressca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1079/BJN19950040ca_ES
dc.relation.ispartofBritish Journal of Nutrition,1995, vol. 73, p. 375-385ca_ES
dc.rights(c) Cambridge University Press, 1995ca_ES
dc.subjectPurine derivativesca_ES
dc.subjectPseudouridineca_ES
dc.subjectPregnancyca_ES
dc.subjectSowca_ES
dc.titleEndogenous purine and pyrimidine derivative excretion in pregnant sowsca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec021680
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1079/BJN19950040


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record