Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models

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2010
Author
Serra Maqueda, Aida
Macià i Puig, Ma Alba
Romero Fabregat, Mª Paz
Valls, Josep
Bladé, Cinta
Arola i Ferrer, Lluís
Motilva Casado, Mª José
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Serra Maqueda, Aida; Macià i Puig, Ma Alba; Romero Fabregat, Mª Paz; Valls, Josep; Bladé, Cinta; Arola i Ferrer, Lluís; Motilva Casado, Mª José; . (2010) . Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. British Journal of Nutrition, 2010, vol. 103, p. 944-952. https://doi.org/10.1017/S0007114509992741.
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Abstract
Among procyanidins (PC), monomers, such as catechin and epicatechin, have been widely studied, whereas dimer and trimer oligomers have received much less attention, despite their abundance in our diet. Recent studies have showed that as dimers and trimers could be important in determining the biological effects of procyanidin-rich food, understanding their bioavailability and metabolism is fundamental. The purpose of the present work is to study the stability of PC under digestion conditions, the metabolism and the bioavailability by using a combination of in vitro and in vivo models. Simultaneously, the matrix effect of a carbohydrate-rich food on the digestibility and bioavailability of PC is investigated. The results show a high level of stability of PC under gastric and duodenal digestion conditions. However, the pharmacokinetic study revealed limited absorption. Free forms of dimers and trimers have been detected in rat plasma, reaching the maximum concentration 1 h after oral intake of a grape seed extract.
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http://hdl.handle.net/10459.1/64880
DOI
https://doi.org/10.1017/S0007114509992741
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British Journal of Nutrition, 2010, vol. 103, p. 944-952
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