Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models

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2010Author
Serra Maqueda, Aida
Valls, Josep
Bladé, Cinta
Arola i Ferrer, Lluís
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Serra Maqueda, Aida;
Macià i Puig, Ma Alba;
Romero Fabregat, Mª Paz;
Valls, Josep;
Bladé, Cinta;
Arola i Ferrer, Lluís;
Motilva Casado, Mª José;
.
(2010)
.
Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models.
British Journal of Nutrition, 2010, vol. 103, p. 944-952.
https://doi.org/10.1017/S0007114509992741.
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Among procyanidins (PC), monomers, such as catechin and epicatechin, have been widely studied, whereas dimer and trimer oligomers have
received much less attention, despite their abundance in our diet. Recent studies have showed that as dimers and trimers could be important in
determining the biological effects of procyanidin-rich food, understanding their bioavailability and metabolism is fundamental. The purpose
of the present work is to study the stability of PC under digestion conditions, the metabolism and the bioavailability by using a combination
of in vitro and in vivo models. Simultaneously, the matrix effect of a carbohydrate-rich food on the digestibility and bioavailability of PC is
investigated. The results show a high level of stability of PC under gastric and duodenal digestion conditions. However, the pharmacokinetic
study revealed limited absorption. Free forms of dimers and trimers have been detected in rat plasma, reaching the maximum concentration
1 h after oral intake of a grape seed extract.
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British Journal of Nutrition, 2010, vol. 103, p. 944-952European research projects
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