Social environment mediates cancer progression in Drosophila
Dawson, Erika H.
Bailly, Tiphaine P. M.
Dos Santos, Julie
MetadataShow full item record
The influence of oncogenic phenomena on the ecology and evolution of animal species is becoming an important research topic. Similar to host–pathogen interactions, cancer negatively affects host fitness, which should lead to the selection of host control mechanisms, including behavioral traits that
best minimize the proliferation of malignant cells. Social behavior is suggested to influence tumor progression. While the ecological benefits of sociality in gregarious species are widely acknowledged, only limited data are available on the role of the social environment on cancer progression. Here, we exposed adult Drosophila, with colorectal-like tumors, to different social environments. We show how subtle variations in social structure have dramatic effects on the progression of tumor growth. Finally, we reveal that flies can discriminate between individuals at different stages of tumor development and selectively choose their social environment accordingly. Our study demonstrates the reciprocal links between cancer and social interactions and how sociality may impact health and fitness in animals and its potential implications for disease ecology.
Is part ofNature Communications, 2018, vol. 9, núm. 3574, p. 1-7
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Erika H. Dawson et al., 2018
Showing items related by title, author, creator and subject.
Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors Campbell,Kyra; Rossi,Fabrizio; Adams, Jamie; Pitsidianaki, Ioanna; Barriga, Francisco M.; Garcia-Gerique, Laura; Batlle, Eduard; Casanova, Jordi; Casali, Andreu (Nature Research, 2019-05-24)Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to the lack of models in vivo. Here we show that expression of the EMT master inducer Snail in primary adult Drosophila ...
Rahman, M.M.; Franch-Marro, X.; Maestro, J.L.; Martin, D.; Casali, Andreu (Nature Publishing Group, 2017-09-15)Hormones play essential roles during development and maintaining homeostasis in adult organisms, regulating a plethora of biological processes. Generally, hormones are secreted by glands and perform a systemic action. Here ...
Tracking progress toward EU biodiversity strategy targets: EU policy effects in preserving its common farmland birds Gamero, Anna; Brotons, Lluís; Brunner, Ariel; Foppen, Ruud; Fornasari, Lorenzo; Gregory, Richard D.; Herrando, Sergi; Hořák, David; Jiguet, Frédéric; Kmecl, Primož; Lehikoinen, Aleksi; Lindström, Åke; Paquet, Jean-Yves; Reif, Jiří; Sirkiä, Päivi M.; Škorpilová, Jana; van Strien, Arco; Szép, Tibor; Telenský, Tomáš; Teufelbauer, Norbert; Trautmann, Sven; van Turnhout, Chris A.M.; Vermouzek, Zdeněk; Vikstrøm, Thomas; Vorisek, P. (Wiley, 2016-08-11)Maximizing the area under biodiversity‐related conservation measures is a main target of the European Union (EU) Biodiversity Strategy to 2020. We analyzed whether agrienvironmental schemes (AES) within EU common agricultural ...