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dc.contributor.authorPascual, Mercè
dc.contributor.authorBatlle Garcia, Jordi de
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorCastro-Grattoni, Anabel L.
dc.contributor.authorAuguet, Josep M.
dc.contributor.authorPascual, Lydia
dc.contributor.authorVilà, Manel
dc.contributor.authorCortijo, Anunciación
dc.contributor.authorSánchez de la Torre, Manuel
dc.date.accessioned2018-10-11T08:13:50Z
dc.date.available2018-10-11T08:13:50Z
dc.date.issued2018
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/64863
dc.description.abstractObjectives Obstructive sleep apnea (OSA) is among the least studied risk factors for erectile dysfunction (ED). We aimed to determine ED prevalence in newly-diagnosed OSA patients, describe their main characteristics and assess continuous positive airway pressure (CPAP) effects on ED. Methods Cross-sectional study assessing ED prevalence in OSA patients and open-label, parallel, prospective randomized controlled trial evaluating 3-month CPAP treatment effects on sexual function, satisfaction, and psychological, hormonal and biochemical profiles. Male patients newly diagnosed with moderate/severe OSA (apnea-hypopnea index >20 events·h−1), aged 18–70 years, attending the sleep unit of a Spanish hospital during 2013–2016 were considered. A total of 150 patients were recruited (75 randomized ED patients). ED was defined as scores <25 on International Index Erectile Function 15 test. Wilcoxon’s matched-pairs signed-ranks and rank-sum tests were used. Results ED prevalence was 51%. Patients with ED were older (p<0.001), had greater waist-to-hip ratios (p<0.001), were more frequently undergoing pharmacological treatment (p<0.001) and had higher glucose levels (p = 0.024) than non-ED patients. Although significant increases in erectile function (mean(SD) change: +4.6(7.9); p = 0.002), overall satisfaction (+1(2.2); p = 0.035), and sexual satisfaction (+2.1(4.3); p = 0.003) were found after CPAP treatment, only differences in sexual satisfaction (p = 0.027) and erectile function (p = 0.060) were found between study arms. CPAP treatment did not impact psychological, hormonal or biochemical profiles. Conclusions This study confirmed the relationship between OSA and ED, suggesting the potential usefulness of ED screening in OSA patients, but could not determine conclusively whether CPAP is an effective stand-alone ED treatment, regardless of positive results on sexual satisfaction.ca_ES
dc.description.sponsorshipThe authors acknowledge funding from "Rafael Mollá y Rodrigo" 2012 clinical research grant (Fundación investigación Urología, Asociación Española de Urología, Spain); and, “SEPAR 2011”research grant (Spanish Society of Pneumology and Thoracic Surgery - SEPAR)ca_ES
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1371/journal.pone.0201930ca_ES
dc.relation.ispartofPlos One, 2018, vol. 13, núm. 8, e0201930ca_ES
dc.rightscc-by (c) Mercè Pascual et al., 2018ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleErectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP)ca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec027338
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0201930


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cc-by (c) Mercè Pascual et al., 2018
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