Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP)
Batlle Garcia, Jordi de
Auguet, Josep M.
MetadataShow full item record
Objectives Obstructive sleep apnea (OSA) is among the least studied risk factors for erectile dysfunction (ED). We aimed to determine ED prevalence in newly-diagnosed OSA patients, describe their main characteristics and assess continuous positive airway pressure (CPAP) effects on ED. Methods Cross-sectional study assessing ED prevalence in OSA patients and open-label, parallel, prospective randomized controlled trial evaluating 3-month CPAP treatment effects on sexual function, satisfaction, and psychological, hormonal and biochemical profiles. Male patients newly diagnosed with moderate/severe OSA (apnea-hypopnea index >20 events·h−1), aged 18–70 years, attending the sleep unit of a Spanish hospital during 2013–2016 were considered. A total of 150 patients were recruited (75 randomized ED patients). ED was defined as scores <25 on International Index Erectile Function 15 test. Wilcoxon’s matched-pairs signed-ranks and rank-sum tests were used. Results ED prevalence was 51%. Patients with ED were older (p<0.001), had greater waist-to-hip ratios (p<0.001), were more frequently undergoing pharmacological treatment (p<0.001) and had higher glucose levels (p = 0.024) than non-ED patients. Although significant increases in erectile function (mean(SD) change: +4.6(7.9); p = 0.002), overall satisfaction (+1(2.2); p = 0.035), and sexual satisfaction (+2.1(4.3); p = 0.003) were found after CPAP treatment, only differences in sexual satisfaction (p = 0.027) and erectile function (p = 0.060) were found between study arms. CPAP treatment did not impact psychological, hormonal or biochemical profiles. Conclusions This study confirmed the relationship between OSA and ED, suggesting the potential usefulness of ED screening in OSA patients, but could not determine conclusively whether CPAP is an effective stand-alone ED treatment, regardless of positive results on sexual satisfaction.
Is part ofPlos One, 2018, vol. 13, núm. 8, e0201930
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Mercè Pascual et al., 2018
Showing items related by title, author, creator and subject.
Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Eventsin Nonsleepy Patients With Obstructive Sleep Apnea Barbé Illa, Ferran; Durán-Cantolla, Joaquín; Sánchez de la Torre, Manuel; Martínez Alonso, Montserrat; Carmona, Carmen; Barceló Bennasar, Antònia; Chiner, Eusebi; Masa, Juan F.; González, Mónica; Marín, J. M.; García Río, Francisco; Díaz de Atauri, María Josefa; Terán, Joaquin; Mayós Pérez, Mercè; Peña, Mónica de la; Monasterio, Carmen; Campo, Félix del; Montserrat i Capdevila, Josep (American Medical Association, 2013)Context Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA). However, its indication for all patients with sleep-disordered breathing, ...
GESAP trial rationale and methodology: management of patients with suspected obstructive sleep apnea in primary care units compared to sleep units Tarraubella Balanya, Núria; Batlle Garcia, Jordi de; Nadal Braque, Núria; Castro-Grattoni, Anabel L.; Gómez Falguera, Silvia; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Nature Publishing Group, 2016-12)BACKGROUND Obstructive sleep apnea syndrome (OSA) is a chronic sleep disorder characterized by repeated episodes of upper airway collapse during sleep. This leads to arterial hypoxemia and sleep disruption and causes daytime ...
Relationship between aldosterone and the metabolic syndrome in patients with obstructive sleep apnea hypopnea syndrome: effect of continuous positive airway pressure treatment Barceló Bennasar, Antònia; Piérola, Javier; Esquinas López, Cristina; Peña, Mónica de la; Arqué, Meritxell; Alonso-Fernández, Alberto; Bauçà, Josep Miquel; Robles, Juan; Barceló, Bernardino; Barbé Illa, Ferran (Public Library of Science, 2014)Methods: We studied 66 patients with OSAHS (33 with MS and 33 without MS) and 35 controls. The occurrence of the MS was analyzed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP ...