Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs
Perez-Pons, Josep Antoni
MetadataShow full item record
Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases and drug targeting. The analysis of the proportion of multitasking proteins
from the MultitaskProtDB-II database shows that 78% of the proteins analyzed are involved in human diseases. This percentage is much higher than the 17.9% found in human proteins in general. A similar analysis using drug target databases shows that 48% of these analyzed human multitasking proteins are targets of current drugs, while only 9.8% of the human proteins present in UniProt are specified as drug targets. In almost 50% of these proteins, both the canonical and moonlighting functions are related to the molecular basis of the disease. A procedure to identify multifunctional proteins from disease databases and a method to structurally map the canonical and moonlighting functions of the protein have also been proposed here. Both of the previous percentages suggest that multitasking is not a rare phenomenon in proteins causing human diseases, and that their detailed study might explain some collateral drug effects.
Is part ofProtein Journal, 2018, vol. 37, núm. 5, p. 444-453
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Luis Franco-Serrano et al., 2018
Showing items related by title, author, creator and subject.
Hernández, Sergio; Ferragut, Gabriela; Amela, Isaac; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique (Oxford University Press, 2014)We have compiled MultitaskProtDB, available online at http://wallace.uab.es/multitask, to provide a repository where the many multitasking proteins found in the literature can be stored. Multitasking or moonlighting ...
Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients Almendros, Isaac; Martínez-García, Miguel Angel; Campos-Rodríguez, Francisco; Riveiro-Falkenbach, Erica; Rodríguez-Peralto, José L.; Nagore, Eduardo; Martorell-Calatayud, Antonio; Hernández Blasco, Luis; Bañuls Roca, Jose; Chiner, Eusebi; Sánchez de la Torre, Alicia; Abad-Capa, Jorge; Montserrat, Josep Maria; Pérez-Gil, Amalia; Cabriada, Valentín; Cano-Pumarega, Irene; Corral-Peñafiel, Jaime; Diaz-Cambriles, Trinidad; Mediano, Olga; Dalmau-Arias, Joan; Farré, Ramon; Gozal, David; Spanish Sleep Network (Frontiers Media, 2018)Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced ...
Alzheimer’s disease mutant mice exhibit reduced brain tissue stiffness compared to wild-type mice in both normoxia and following intermittent hypoxia mimicking sleep apnea Menal Castellote, Maria José; Jorba, Ignasi; Torres, Marta; Montserrat i Capdevila, Josep; Gozal, David; Colell, Anna; Piñol Ripoll, Gerard; Navajas, Daniel; Almendros, Isaac; Farré, Ramon (Frontiers Media, 2018)Background: Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer’s disease (AD) and that AD is associated with reduced brain tissue stiffness. Aim: To ...