Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs

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2018
Author
Franco-Serrano, Luis
Huerta, Mario
Hernández, Sergio
Cedano, Juan
Perez-Pons, Josep Antoni
Piñol, Jaume
Mozo Villarías, Angel
Amela, Isaac
Querol, Enrique
Suggested citation
Franco-Serrano, Luis; Huerta, Mario; Hernández, Sergio; Cedano, Juan; Perez-Pons, Josep Antoni; Piñol, Jaume; ... Querol, Enrique. (2018) . Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs. Protein Journal, 2018, vol. 37, núm. 5, p. 444-453. https://doi.org/10.1007/s10930-018-9790-x.
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Abstract
Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases and drug targeting. The analysis of the proportion of multitasking proteins
from the MultitaskProtDB-II database shows that 78% of the proteins analyzed are involved in human diseases. This percentage is much higher than the 17.9% found in human proteins in general. A similar analysis using drug target databases shows that 48% of these analyzed human multitasking proteins are targets of current drugs, while only 9.8% of the human proteins present in UniProt are specified as drug targets. In almost 50% of these proteins, both the canonical and moonlighting functions are related to the molecular basis of the disease. A procedure to identify multifunctional proteins from disease databases and a method to structurally map the canonical and moonlighting functions of the protein have also been proposed here. Both of the previous percentages suggest that multitasking is not a rare phenomenon in proteins causing human diseases, and that their detailed study might explain some collateral drug effects.
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http://hdl.handle.net/10459.1/64852
DOI
https://doi.org/10.1007/s10930-018-9790-x
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Protein Journal, 2018, vol. 37, núm. 5, p. 444-453
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cc-by (c) Luis Franco-Serrano et al., 2018
Except where otherwise noted, this item's license is described as cc-by (c) Luis Franco-Serrano et al., 2018