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dc.contributor.authorGarcía de la Fuente, María Reyes
dc.contributor.authorSantacana Espasa, Maria
dc.contributor.authorValls Marsal, Joan
dc.contributor.authorVilardell, Felip
dc.contributor.authorFernández Armenteros, José Manuel
dc.contributor.authorPujol Vallverdú, Ramón M.
dc.contributor.authorGarí Marsol, Eloi
dc.contributor.authorCasanova i Seuma, Josep M. (Josep Manel)
dc.description.abstractBasal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non–sun-exposed areas, including hairless regions, was evaluated. The authors have observed that CK7 expression in BCC is associated with the anatomical localization of the tumor and its sun-exposition, but not with other factors such as histological subtype. The expression of this CK is higher in BCCs located in non–sun-exposed and nonhairy areas, such as the vulvar semimucosa and the nipple. Because CK7 is a marker of simple glandular epithelia, the authors suggest a glandular origin for BCCs located in hairless and nonphotoexposed areas.ca_ES
dc.publisherWolters Kluwer Health, Inc.ca_ES
dc.publisherInternational Society of Dermatopathology (ISDP)ca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofThe American Journal of Dermatopathology, 2018, vol. 40, núm. 5, p. 342–348ca_ES
dc.rightscc-by-nc-nd (c) María Reyes García de la Fuente et al., 2018ca_ES
dc.subjectBasal cell carcinomaca_ES
dc.subjectHair follicleca_ES
dc.subjectSebaceous glandca_ES
dc.titleCytokeratin profile of basal cell carcinomas according to the degree of sun exposure and to the anatomical localizationca_ES

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cc-by-nc-nd (c) María Reyes García de la Fuente et al., 2018
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) María Reyes García de la Fuente et al., 2018