Cytokeratin profile of basal cell carcinomas according to the degree of sun exposure and to the anatomical localization
García de la Fuente, María Reyes
Santacana Espasa, Maria
Valls Marsal, Joan
Fernández Armenteros, José Manuel
MetadataShow full item record
Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non–sun-exposed areas, including hairless regions, was evaluated. The authors have observed that CK7 expression in BCC is associated with the anatomical localization of the tumor and its sun-exposition, but not with other factors such as histological subtype. The expression of this CK is higher in BCCs located in non–sun-exposed and nonhairy areas, such as the vulvar semimucosa and the nipple. Because CK7 is a marker of simple glandular epithelia, the authors suggest a glandular origin for BCCs located in hairless and nonphotoexposed areas.
Is part ofThe American Journal of Dermatopathology, 2018, vol. 40, núm. 5, p. 342–348
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) María Reyes García de la Fuente et al., 2018
Showing items related by title, author, creator and subject.
Fernández Armenteros, José Manuel; Gómez Arbonés, Javier; Buti, Miquel; Betriu i Bars, M. Àngels; Sanmartín Novell, Verònica; Ortega Bravo, Marta; Martínez Alonso, Montserrat; Garí Marsol, Eloi; Portero Otín, Manuel; Santamaria-Babi, L.; Casanova i Seuma, Josep M. (Josep Manel) (Wiley, 2019)Abstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and ...
Cortés, Camila; Bielsa Martín, Silvia; Fernández, Josep Manel; Vilardell, Felip; Gonzalez-Farré, Blanca; Casanova i Seuma, Josep M. (Josep Manel) (Society for Publication of Acta Dermato-Venereologica, 2018)IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition characterized mainly by tissue infiltration by IgG4+ plasma cells with a tendency to mass forming. IgG4-RD can involve any part of the body, including ...
Fernández Armenteros, José Manuel; Molinero Ponce, Isabel; Castan Campanera, Ester; Casanova i Seuma, Josep M. (Josep Manel) (Elsevier, 2016)La psicodermatología es una rama común a la dermatología y la psiquiatría. Se centra en el estudio de las manifestaciones cuta´neas producidas por alteraciones psiquiátricas. Es una disciplina situada en áreas comunes ...