Show simple item record

dc.contributor.authorMartín, Marisa
dc.contributor.authorValls Marsal, Joan
dc.contributor.authorBetriu i Bars, M. Àngels
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorValdivielso Revilla, José Manuel
dc.date.accessioned2018-06-15T11:59:01Z
dc.date.available2018-06-15T11:59:01Z
dc.date.issued2015-02-28
dc.identifier.issn0021-9150
dc.identifier.urihttp://hdl.handle.net/10459.1/64520
dc.description.abstractAbstract BACKGROUND: Cardiovascular disease is the leading cause of mortality in chronic kidney disease (CKD). Serum phosphate has been associated to cardiovascular disease in the general population and this effect seems to be different according to sex. In the present study we analyze the effect of phosphate on subclinical atherosclerosis in the NEFRONA population and its effect depending on sex. DESIGN: Carotid ultrasound assessing the presence of plaques was performed by an itinerant team in 1687 CKD patients not in dialysis without previous cardiovascular events. Standard blood test and anthropometrical parameters were also recorded. RESULTS: Multivariate linear regression to model phosphate levels in patients with CKD showed an interaction of sex with age. Thus, among men, serum phosphate levels declined significantly with age almost linearly. Serum phosphate levels in women under the age of 40-45 years overlapped with those in men and then stayed above, showing and overall constant relationship. Multivariate logistic regression analysis showed that higher phosphate levels associated with a higher risk of presenting atheromatous plaque. This risk however was different according to sex. In men, phosphate levels within the normal range associated with an increased risk of subclinical atheromatosis whereas in women this risk only increased with serum levels over the normal range. CONCLUSIONS: This study demonstrates that phosphate levels are associated with the presence of subclinical atheromatosis in a large CKD population. This effect of phosphate on subclinical atheromatosis was different according to sex, suggesting that a recommended serum phosphate levels could be different for male than for female CKD patients.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.atherosclerosis.2015.02.048
dc.relation.ispartofAtherosclerosis, 2015, vol. 241, núm. 1, p. 264-270
dc.rights(c) Elsevier Ireland, 2015
dc.subjectPhosphate
dc.subjectChronic kidney disease
dc.subjectAtheromatosis
dc.titleAssociation of serum phosphorus with subclinical atherosclerosis in chronic kidney disease. Sex makes a difference
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-06-15T11:59:01Z
dc.identifier.idgrec023300
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1016/j.atherosclerosis.2015.02.048


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record