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dc.contributor.authorCarmona, Andrés
dc.contributor.authorAgüera, Maria L.
dc.contributor.authorLuna-Ruiz, Carlos
dc.contributor.authorBuendía, Paula
dc.contributor.authorCalleros-Basilio, Laura
dc.contributor.authorGarcía-Jerez, Andrea
dc.contributor.authorRodríguez-Puyol, Manuel
dc.contributor.authorArias, Manuel
dc.contributor.authorArias-Guillen, Marta
dc.contributor.authorArriba, Gabriel de
dc.contributor.authorBallarin, José
dc.contributor.authorBernis, Carmen
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorGarcía-Rebollo, Sagrario
dc.contributor.authorMancha, Javier
dc.contributor.authorPeso, Gloria del
dc.contributor.authorPérez, Estefanía
dc.contributor.authorPoch, Esteban
dc.contributor.authorPortolés, José M.
dc.contributor.authorRodríguez-Puyol, Diego
dc.contributor.authorSánchez-Villanueva, Rafael
dc.contributor.authorSarró, Felipe
dc.contributor.authorTorres, Armando
dc.contributor.authorMartín-Malo, Alejandro
dc.contributor.authorAljama, Pedro
dc.contributor.authorRamírez, Rafael
dc.contributor.authorCarracedo, Júlia
dc.date.accessioned2018-06-15T11:02:28Z
dc.date.available2018-06-15T11:02:28Z
dc.date.issued2017-04-01
dc.identifier.issn0363-6127
dc.identifier.urihttp://hdl.handle.net/10459.1/64518
dc.description.abstractPatients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins (Ang) to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (Madrid, Spain): 80 patients with DM and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD142+/CD16+, CD14+/CD162+) were analyzed by flow cytometry, and the plasma concentrations of Ang1 and Ang2 were quantified by ELISA. Data on CVD were gathered over the 5.5 yr after these samples were obtained. MV level, monocyte subpopulations (CD14+/CD162+ and CD142+/CD16+), and Ang2-to-Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/µl) was associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2-to-Ang1 ratio can be used as predictors for CVD. In addition, MV level has a potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM.
dc.description.sponsorshipSupport for this work was provided by Plan Nacional de IDi Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)–Subdirección General de Evaluación, Fondos de desarrollo regional (FEDER; PI11/01536, PI12/01489, PI14/00806, PI15/01785); Junta de Andalucía grants (P010-CTS-6337, P11-CTS-7352); and Fundación Nefrológica. P. Buendía, A. Carmona, and C. Luna-Ruiz are fellows from Consejería de Innovacion, Ciencia y Empresa, Junta de Andalucía.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1152/ajprenal.00013.2016
dc.relation.ispartofAmerican Journal of Physiology-Renal Physiology, 2017, vol. 312, núm. 4, p. 673-681
dc.rights(c) The American Physiological Society, 2017
dc.subjectChronic kidney disease
dc.subjectCardiovascular disease
dc.subjectDiabetes mellitus
dc.titleMarkers of endothelial damage in patients with chronic kidney disease on hemodialysis
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-06-15T11:02:28Z
dc.identifier.idgrec025662
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1152/ajprenal.00013.2016


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