Colonic metabolism of phenolic compounds: from in vitro to in vivo approaches
Universitat de Lleida. Departament de Tecnologia d'Aliments
MetadataShow full item record
Phenolic compounds are a group phytochemicals widely but not uniform distributed in the plant kingdom. These compounds have generated great expectations in the scientific community as natural therapeutics due to their antioxidant, anti-inflammatory and anticarcinogenic properties. Initial attention was concentrated to study the bioavailability of the native compounds present in the food. Nevertheless, their aparent low bioavailability has awake the possibility to contemplate other related metabolites rather than the original forms. In the obstinacy to really cover the general metabolism of phenolic compounds in the human body, their colonic fate has gained a central role. The different works that make up the body of this Doctoral Thesis are focused in the study of the colonic metabolism of the more representative phenolic compounds present in three plan-based products. The products concerned were enriched olive oil in its own phenolic compounds and in combination with thyme phenolic compounds, pomegranate and Arbutus unedo fruit. In vitro fermentations and human interventions were conducted with the purpose of exploring the fate of phenolic compounds in the gut.
European research projects
- Tesis Doctorals 
Showing items related by title, author, creator and subject.
Advances in the knowledge of olive oil phenolic compounds. From biotransformations after their intake to their metabolic fate for exerting biological activities López de las Hazas Mingo, María del Carmen (Universitat de Lleida, 2017-03-17)
Metabolic and Microbial Modulation of the Large Intestine Ecosystem by Non-Absorbed Diet Phenolic Compounds: A Review Motilva Casado, Mª José; Macià i Puig, Ma Alba; Mosele, Juana (MDPI, 2015)Phenolic compounds represent a diverse group of phytochemicals whose intake is associated with a wide spectrum of health benefits. As consequence of their low bioavailability, most of them reach the large intestine where, ...
Mosele, Juana; Martín Peláez, Sandra María; Macià i Puig, Ma Alba; Farràs, Marta; Valls, Rosa M.; Catalán Santos, Úrsula; Motilva Casado, Mª José (John Wiley & Sons, 2014)In the present study, the individual colonic metabolism of the main components of the virgin olive oil phenolic fraction was evaluated by an in vitro model using human faecal microbiota. To assess differences in metabolism ...