Universitat de Lleida
    • English
    • català
    • español
  • español 
    • English
    • català
    • español
  • Iniciar sesión
Repositori Obert UdL
Ver ítem 
  •   Inicio
  • Recerca
  • Medicina Experimental
  • Articles publicats (Medicina Experimental)
  • Ver ítem
  •   Inicio
  • Recerca
  • Medicina Experimental
  • Articles publicats (Medicina Experimental)
  • Ver ítem
JavaScript is disabled for your browser. Some features of this site may not work without it.

A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium

Thumbnail
Ver/Abrir
Postprint (11.42Mb)
Fecha de publicación
2017-05-19
Autor/a
Eritja Sánchez, Núria
Felip, Isidre
Dosil Garcia, Maria Alba
Vigezzi, Lucia
Mirantes Barbeito, Cristina
Yeramian Hakim, Andree
Navaridas Fernández de Bobadilla, Raúl
Santacana Espasa, Maria
Llobet Navàs, David
Yoshimura, Akihiko
Nomura, Masatoshi
Encinas Martín, Mario
Matias-Guiu, Xavier
Dolcet Roca, Xavier
Cita recomendada
Eritja Sánchez, Núria; Felip, Isidre; Dosil Garcia, Maria Alba; Vigezzi, Lucia; Mirantes Barbeito, Cristina; Yeramian Hakim, Andree; ... Dolcet Roca, Xavier. (2017) . A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium. Cell Death and Differentiation, 2017, vol. 24, núm. 8, p. 1443-1458. https://doi.org/10.1038/cdd.2017.73.
Impacto


Logo de Web of Science    citaciones en Web of Science

Logo de Scopus    citaciones en Scopus

Logo de Google Académico  Google Académico
Compartir
Exportar a Mendeley
Metadatos
Mostrar el registro completo del ítem
Resumen
The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it is a tumor promoter for cancerous cells. Such dichotomous actions are dictated by different cellular contexts. Here, we have unveiled a PTEN-Smad3 regulatory loop that provides a new insight in the complex cross talk between TGF-β/Smad and PI3K/AKT signaling pathways. We demonstrate that TGF-β triggers apoptosis of wild-type polarized endometrial epithelial cells by a Smad3-dependent activation of PTEN transcription, which results in the inhibition of PI3K/AKT signaling pathway. We show that specific Smad3 knockdown or knockout reduces basal and TGF-β-induced PTEN expression in endometrial cells, resulting in a blockade of TGF-β-induced apoptosis and an enhancement of cell proliferation. Likewise Smad3 deletion, PTEN knockout prevents TGF-β-induced apoptosis and increases cell proliferation by increasing PI3K/AKT/mTOR signaling. In summary, our results demonstrate that Smad3-PTEN signaling axis determine cellular responses to TGF-β.
URI
http://hdl.handle.net/10459.1/63501
DOI
https://doi.org/10.1038/cdd.2017.73
Es parte de
Cell Death and Differentiation, 2017, vol. 24, núm. 8, p. 1443-1458
Proyectos de investigación europeos
Colecciones
  • Articles publicats (Medicina Experimental) [323]
  • Articles publicats (Ciències Mèdiques Bàsiques) [548]
  • Publicacions de projectes de recerca del Plan Nacional [2638]
  • Articles publicats (IRBLleida) [1055]

Contacto | Sugerencias | Aviso legal
© 2022 BiD. Universitat de Lleida
Metadatos sujetos a 
 

 

Explorar

Todo el repositorioComunidades y coleccionesPor fecha de publicaciónAutoresTítulosMateriasEsta colecciónPor fecha de publicaciónAutoresTítulosMaterias

Estadísticas

Ver Estadísticas de uso

De interés

Política institucional d'accés obertDiposita les teves publicacionsDiposita dades de recercaSuport a la recerca

Contacto | Sugerencias | Aviso legal
© 2022 BiD. Universitat de Lleida
Metadatos sujetos a