Safety of cilostazol in peripheral artery disease: a cohort from a primary healthcare electronic database
MetadataShow full item record
Background: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users. Methods: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009–2011 in SIDIAP database. The two treatment groups were matched through propensity score (PS). Results: Nine thousand one hundred twenty-nine patients met inclusion criteria and after PS matching, there were 2905 patients in each group. 76% of patients were men, with similar mean ages in both groups (68.8 for cilostazol and 69.4 for pentoxifylline). There were no differences in bleeding, cerebrovascular and cardiovascular events between both groups. Conclusions: Patients treated with cilostazol were different from those treated with pentoxifylline at baseline, so they were matched through PS. We did not find differences between treatment groups in the incidence of bleeding or cardiovascular and cerebrovascular events. Cilostazol should be used with precaution in elderly polymedicated patients.
Is part ofBMC Cardiovascular Disorders, 2018, vol. 18, núm. 85, p.1-7
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Ischemic heart disease and primary care: identifying gender-related differences. An observational study Cruz Esteve, María Inés; Serna Arnaiz, Catalina; Real, Jordi; Galindo Ortego, Gisela; Gascó, Eduardo; Galván, Leonardo (BioMed Central, 2008)Background: Gender-related differences are seen in multiple aspects of both health and illness. Ischemic heart disease (IHD) is a pathology in which diagnostic, treatment and prognostic differences are seen between sexes, ...
Soler González, Jorge; Marsal Mora, Josep Ramon; Serna Arnaiz, Catalina; Real, Jordi; Cruz Esteve, María Inés; López, Albert (Sociedad Española de Salud Pública y Administración Sanitaria (SESPAS)Elsevier, 2013)Introducción: Se sabe que hay diferencias entre los grupos de inmigrantes en lo que respecta a la prevalencia de diabetes, pero no disponemos de suficiente evidencia para afirmar que, una vez diagnosticada, sea distinto ...
Soler González, Jorge; Ruiz-Magaz, Maria Cristina; Serna Arnaiz, Catalina; Marsal Mora, Josep Ramon (BioMed Central, 2011)Background: Providing support for research is one of the key issues in the ongoing attempts to improve Primary Care. However, when patient care takes up a significant part of a GP's time, conducting research is difficult. ...