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dc.contributor.authorCarbonell, Marc
dc.contributor.authorCastelblanco Echavarría, Esmeralda
dc.contributor.authorValldeperas, Xavier
dc.contributor.authorBetriu i Bars, M. Àngels
dc.contributor.authorTraveset Maeso, Alicia
dc.contributor.authorGranado Casas, Minerva
dc.contributor.authorHernández García, Marta
dc.contributor.authorVázquez, Federico
dc.contributor.authorMartín, Mariona
dc.contributor.authorRubinat, Esther
dc.contributor.authorLecube Torelló, Albert
dc.contributor.authorFranch-Nadal, Josep
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorPuig-Domingo, Manuel
dc.contributor.authorAvogaro, Angelo
dc.contributor.authorAlonso, Núria
dc.contributor.authorMauricio Puente, Dídac
dc.date.accessioned2018-05-09T11:04:20Z
dc.date.available2018-05-09T11:04:20Z
dc.date.issued2018-05-04
dc.identifier.issn1475-2840
dc.identifier.urihttp://hdl.handle.net/10459.1/63260
dc.description.abstractBackground: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results: In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions: In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.
dc.description.sponsorshipThis research was supported by grants from the Spanish Ministry of Health, the Carlos III National Institute of Health (PI12/0183 and PI15/0625) and European Regional Development Fund (ERDF). CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative of ISCIII, Spain.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1186/s12933-018-0706-z
dc.relation.ispartofCardiovascular Diabetology, 2018, vol. 17, núm. 66, p. 1-10
dc.rightscc-by (c) Carbonell, Marc et al., 2018
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.subject.classificationDiabetis
dc.subject.classificationRetinopatia diabètica
dc.subject.classificationAterosclerosi
dc.subject.otherDiabetes
dc.subject.otherDiabetic retinopathy
dc.subject.otherAtherosclerosis
dc.titleDiabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-05-09T11:04:23Z
dc.identifier.idgrec027007
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1186/s12933-018-0706-z


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cc-by (c) Carbonell, Marc et al., 2018
Except where otherwise noted, this item's license is described as cc-by (c) Carbonell, Marc et al., 2018