Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
Castelblanco Echavarría, Esmeralda
Traveset Maeso, Alicia
MetadataShow full item record
Background: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results: In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions: In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.
Is part ofCardiovascular Diabetology, 2018, vol. 17, núm. 66, p. 1-10
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by (c) Carbonell, Marc et al., 2018
Showing items related by title, author, creator and subject.
Granado Casas, Minerva; Ramírez-Morros, Anna; Martín, Mariona; Real, Jordi; Alonso, Núria; Valldeperas, Xavier; Traveset Maeso, Alicia; Rubinat, Esther; Alcubierre Calvo, Núria; Hernández García, Marta; Puig-Domingo, Manuel; Lecube Torelló, Albert; Castelblanco Echavarría, Esmeralda; Mauricio Puente, Dídac (MDPI, 2018-08-29)Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetes management and its diabetic complications. Our ...
Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes Castelblanco Echavarría, Esmeralda; Betriu i Bars, M. Àngels; Hernández, Marta; Granado Casas, Minerva; Ortega, Emilio; Soldevila, Berta; Ramírez-Morros, Anna; Franch-Nadal, Josep; Puig-Domingo, Manuel; Fernández i Giráldez, Elvira; Avogaro, Angelo; Alonso, Núria; Mauricio Puente, Dídac (MDPI, 2019-03-28)The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of ...
Increased Burden of Cerebral Small Vessel Disease in Patients With Type 2 Diabetes and Retinopathy Sanahuja Montesinos, Jordi; Alonso, Núria; Diez, Javier; Ortega, Emilio; Rubinat, Esther; Traveset Maeso, Alicia; Alcubierre Calvo, Núria; Betriu i Bars, M. Àngels; Castelblanco Echavarría, Esmeralda; Hernández García, Marta; Purroy Garcia, Francisco; Arcidiacono, Maria V.; Jurjo Campo, Carmen; Fernández i Giráldez, Elvira; Puig-Domingo, Manuel; Groop, Per-Henrik; Mauricio Puente, Dídac (American Diabetes Association, 2016-06-08)OBJECTIVE We sought to examine the presence and severity of brain small vessel disease (SVD) in patients with type 2 diabetes and diabetic retinopathy (DR) compared with those without DR. RESEARCH DESIGN AND METHODS We ...