Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes

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2018-05-04
Author
Carbonell, Marc
Castelblanco Echavarría, Esmeralda
Valldeperas, Xavier
Betriu i Bars, M. Àngels
Traveset Maeso, Alicia
Granado Casas, Minerva
Hernández García, Marta
Vázquez, Federico
Martín, Mariona
Rubinat, Esther
Lecube Torelló, Albert
Franch-Nadal, Josep
Fernández i Giráldez, Elvira
Puig-Domingo, Manuel
Avogaro, Angelo
Alonso, Núria
Mauricio Puente, Dídac
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Carbonell, Marc; Castelblanco Echavarría, Esmeralda; Valldeperas, Xavier; Betriu i Bars, M. Àngels; Traveset Maeso, Alicia; Granado Casas, Minerva; ... Mauricio Puente, Dídac. (2018) . Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes. Cardiovascular Diabetology, 2018, vol. 17, núm. 66, p. 1-10. https://doi.org/10.1186/s12933-018-0706-z.
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Abstract
Background: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results: In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions: In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.
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http://hdl.handle.net/10459.1/63260
DOI
https://doi.org/10.1186/s12933-018-0706-z
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Cardiovascular Diabetology, 2018, vol. 17, núm. 66, p. 1-10
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cc-by (c) Carbonell, Marc et al., 2018
Except where otherwise noted, this item's license is described as cc-by (c) Carbonell, Marc et al., 2018