Cardiac troponin values in patients with acute coronary syndrome and sleep apnea: a pilot study
Sánchez de la Torre, Alicia
Valls Marsal, Joan
Batlle Garcia, Jordi de
MetadataShow full item record
Background: An analysis of cardiac injury markers in patients with OSA who sustain an episode of acute coronary syndrome (ACS) may contribute to a better understanding of the interactions and impact of OSA in subjects with ACS. We compared peak cardiac troponin I (cTnI) levels in patients with OSA and patients without OSA who were admitted for ACS. Methods: Blood samples were collected every 6 hours from the time of admission until two consecutive assays showed a downward trend in the cTnI assay. The highest value obtained defined the peak cTnI value, which provides an estimate of infarct size. Results: We included 89 patients with OSA and 38 patients without OSA with an apnea-hypopnea index of a median of 32 (interquartile range [IQR], 20.8-46.6/h and 4.8 [IQR, 1.6-9.6]/h, respectively. The peak cTnI value was significantly higher in patients without OSA than in patients with OSA (median, 10.7 ng/mL [IQR, 1.78-40.1 ng/mL] vs 3.79 ng/mL [IQR, 0.37-24.3 ng/mL]; P = .04). The multivariable linear regression analysis of the relationship between peak cTnI value and patient group, age, sex, and type of ACS showed that the presence or absence of OSA significantly contributed to the peak cTnI level, which was 54% lower in patients with OSA than in those without OSA. Conclusions: The results of this study suggest that OSA has a protective effect in the context of myocardial infarction and that patients with OSA may experience less severe myocardial injury. The possible role of OSA in cardioprotection should be explored in future studies.
Is part ofChest, 2018, vol. 153, núm. 2, p. 329-338
European research projects
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome Florés, Marina; Batlle Garcia, Jordi de; Sánchez de la Torre, Alicia; Sánchez de la Torre, Manuel; Aldomá, Albina; Worner, Fernando; Galera, Estefanía; Seminario, Asunción; Torres, Gerard; Dalmases, Mireia; Montserrat i Capdevila, Josep; Garmendia, Onintza; Barbé Illa, Ferran (Public Library of Science, 2016)Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and ...
Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome Barbé Illa, Ferran; Sánchez de la Torre, Alicia; Abad, Jorge; Durán-Cantolla, Joaquín; Mediano, Olga; Amilibia, Jose; Masdeu, María José; Florés, Marina; Barceló Bennasar, Antònia; Peña, Mónica de la; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Castellà, Gerard; Sánchez de la Torre, Manuel (European Respiratory Society, 2015)The goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an ...
Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome Sánchez de la Torre, Alicia; Abad, Jorge; Durán-Cantolla, Joaquín; Mediano, Olga; Cabriada, Valentín; Masdeu, María José; Terán, Joaquin; Masa, Juan F.; Peña, Mónica de la; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Public Library of Science, 2016)Background: The cardiovascular consequences of obstructive sleep apnoea (OSA) differ by sex. We hypothesized that sex influences the severity of acute coronary syndrome (ACS) in patients with OSA. OSA was defined as an ...