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dc.contributor.authorPedraza González, Neus
dc.contributor.authorCemeli, Tània
dc.contributor.authorMonserrat Monserrat, Maria Ventura
dc.contributor.authorGarí Marsol, Eloi
dc.contributor.authorFerrezuelo, Francisco
dc.date.accessioned2018-04-05T08:27:12Z
dc.date.available2018-04-05T08:27:12Z
dc.date.issued2017-01-27
dc.identifier.issn2154-1248
dc.identifier.urihttp://hdl.handle.net/10459.1/63048
dc.description.abstractTogether with a cyclin-dependent kinase (CDK) partner G1 cyclins control cell cycle entry by phosphorylating a number of nuclear targets and releasing a transcriptional program at the end of G1 phase. Yeast G1 cyclins also operate on cytoplasmic targets involved in the polarization of the cytoskeleton and vesicle trafficking. These processes are mainly controlled by the small GTPase Cdc42, and G1 cyclins regulate the activity of this and other small GTPases through the modulation of their regulators and effectors. This regulation is key for different developmental outcomes in unicellular organisms. In mammalian cells cytoplasmic G1 cyclin D1 has been shown to promote the activity of Rac1 and Ral GTPases and to block RhoA. Regulation of these small GTPases by G1 cyclins may constitute a mechanism to coordinate proliferation with cell migration and morphogenesis, important processes not only during normal development and organogenesis but also for tumor formation and metastasis. Here we briefly review the evidence supporting a role of G1 cyclins and CDKs as regulators of the activity of small GTPases, emphasizing their functional relevance both in budding yeast and in mammalian cells.
dc.description.sponsorshipThis work was funded by Spanish Ministry of Education and Science (BFU2013-42895) from the Spanish Ministry of Economy and Competitivity and Catalan Government (SGR-559). T. Cemeli and MV Monserrat were supported by predoctoral fellowships from Spanish Ministry of Education and Science (FPU) and from University of Lleida, respectively.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relationMINECO/PN2013-2016/BFU2013-42895
dc.relation.isformatofVersió postprint del document publicat a https://doi.org/10.1080/21541248.2016.1268665
dc.relation.ispartofSmall GTPases, 2019, vol. 10, núm. 1, p. 47-53
dc.rights(c) Taylor & Francis, 2017
dc.subjectG1 cyclins
dc.subjectSmall GTPases
dc.subjectYeast
dc.subjectMammals
dc.subjectCell polarity
dc.titleRegulation of small GTPase activity by G1 cyclins
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-04-05T08:27:13Z
dc.identifier.idgrec025811
dc.type.versionacceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1080/21541248.2016.1268665


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