Regulation of small GTPase activity by G1 cyclins

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Issue date
2017-01-27
Author
Pedraza González, Neus
Cemeli, Tània
Monserrat Monserrat, Maria Ventura
Garí Marsol, Eloi
Ferrezuelo, Francisco
Suggested citation
Pedraza González, Neus; Cemeli, Tània; Monserrat Monserrat, Maria Ventura; Garí Marsol, Eloi; Ferrezuelo, Francisco; . (2017) . Regulation of small GTPase activity by G1 cyclins. Small GTPases, 2019, vol. 10, núm. 1, p. 47-53. https://doi.org/10.1080/21541248.2016.1268665.
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Abstract
Together with a cyclin-dependent kinase (CDK) partner G1 cyclins control cell cycle entry by phosphorylating a number of nuclear targets and releasing a transcriptional program at the end of G1 phase. Yeast G1 cyclins also operate on cytoplasmic targets involved in the polarization of the cytoskeleton and vesicle trafficking. These processes are mainly controlled by the small GTPase Cdc42, and G1 cyclins regulate the activity of this and other small GTPases through the modulation of their regulators and effectors. This regulation is key for different developmental outcomes in unicellular organisms. In mammalian cells cytoplasmic G1 cyclin D1 has been shown to promote the activity of Rac1 and Ral GTPases and to block RhoA. Regulation of these small GTPases by G1 cyclins may constitute a mechanism to coordinate proliferation with cell migration and morphogenesis, important processes not only during normal development and organogenesis but also for tumor formation and metastasis. Here we briefly review the evidence supporting a role of G1 cyclins and CDKs as regulators of the activity of small GTPases, emphasizing their functional relevance both in budding yeast and in mammalian cells.
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http://hdl.handle.net/10459.1/63048
DOI
https://doi.org/10.1080/21541248.2016.1268665
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Small GTPases, 2019, vol. 10, núm. 1, p. 47-53
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