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dc.contributor.authorCicvaric, Ana
dc.contributor.authorYang, Jiaye
dc.contributor.authorBulat, Tanja
dc.contributor.authorZambon, Alice
dc.contributor.authorDominguez-Rodriguez, Manuel
dc.contributor.authorKühn, Rebekka
dc.contributor.authorSadowicz, Michael G.
dc.contributor.authorSiwert, Anjana
dc.contributor.authorEgea Navarro, Joaquim
dc.contributor.authorPollak, Daniela D.
dc.contributor.authorMoeslinger, Thomas
dc.contributor.authorMonje, Francisco J.
dc.description.abstractThe Fibronectin Leucine-Rich Transmembrane protein 2 (FLRT2) has been implicated in several hormone -and sex-dependent physiological and pathological processes (including chondrogenesis, menarche and breast cancer); is known to regulate developmental synapses formation, and is expressed in the hippocampus, a brain structure central for learning and memory. However, the role of FLRT2 in the adult hippocampus and its relevance in sex-dependent brain functions remains unknown. We here used adult single-allele FLRT2 knockout (FLRT2+/−) mice and behavioral, electrophysiological, and molecular/biological assays to examine the effects of FLRT2 haplodeficiency on synaptic plasticity and hippocampus-dependent learning and memory. Female and male FLRT2+/− mice presented morphological features (including body masses, brain shapes/weights, and brain macroscopic cytoarchitectonic organization), indistinguishable from their wild type counterparts. However, in vivo examinations unveiled enhanced hippocampus-dependent spatial memory recall in female FLRT2+/− animals, concomitant with augmented hippocampal synaptic plasticity and decreased levels of the glutamate transporter EAAT2 and beta estrogen receptors. In contrast, male FLRT2+/− animals exhibited deficient memory recall and decreased alpha estrogen receptor levels. These observations propose that FLRT2 can regulate memory functions in the adulthood in a sex-specific manner and might thus contribute to further research on the mechanisms linking sexual dimorphism and cognition.ca_ES
dc.description.sponsorshipFJM was supported by Siemens (Healthcare GmbH) and by the Austrian Science Fund (FWF: P27551). DDP is supported by the Austrian Science Fund (FWF): P27520, P28683, and W1205.ca_ES
dc.publisherNature Publishing Groupca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofScientific Reports, 2018, vol. 8, núm. 3703, p. 1-13ca_ES
dc.rightscc-by (c) Cicvaric et al., 2018ca_ES
dc.titleEnhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient miceca_ES

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