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dc.contributor.authorEstiarte, Núria
dc.contributor.authorLawrence, C. B.
dc.contributor.authorSanchís Almenar, Vicente
dc.contributor.authorRamos Girona, Antonio J.
dc.contributor.authorCrespo Sempere, Ana
dc.date.accessioned2018-04-03T10:44:32Z
dc.date.available2018-04-03T10:44:32Z
dc.date.issued2016
dc.identifier.issn0168-1605
dc.identifier.urihttp://hdl.handle.net/10459.1/62954
dc.description.abstractAlternaria alternata is a common filamentous fungus that contaminates various fruits, grains and vegetables causing important economic losses to farmers and the food industry. A. alternata is a mycotoxigenic mould, which may jeopardize human and animal health. Two of the most common A. alternata mycotoxins found in food and feed are alternariol and alternariol monomethyl ether. In this study we examined the role of LaeA and VeA, two regulatory proteins belonging to the velvet family, which have been described to be involved in several functions in many fungi including secondary metabolism. We found that deletion of laeA and veA genes, respectively, greatly reduced sporulation and strongly compromised mycotoxin production, both in vitro or during pathogenesis of tomato fruits. We have also studied how the loss of laeA and veA may affect expression of genes related to alternariol and alternariol monomethyl ether biosynthesis (pksJ and altR), and to melanin biosynthesis (cmrA, pksA).
dc.description.sponsorshipWe are also grateful to the Catalonian Government (XaRTA-Reference Network on Food Technology) for their financial support. N. Estiarte thanks the Secretaria de Universitats i Recerca del Departament d'Economia i Coneixement of the Generalitat de Catalunya for the pre-doctoral grant (FI-DGR 2013).
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.ijfoodmicro.2016.09.003
dc.relation.ispartofInternational Journal of Food Microbiology, 2016, vol. 238, p. 153-164
dc.rightscc-by-nc-nd (c) Elsevier, 2016
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectAlternaria alternata
dc.subjectVelvet complex
dc.subjectVeA
dc.subjectLaeA
dc.subject.otherAlternàries
dc.subject.otherMicotoxines
dc.titleLaeA and VeA are involved in growth morphology, asexual development, and mycotoxin production in Alternaria alternata
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-04-03T10:44:32Z
dc.identifier.idgrec024707
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1016/j.ijfoodmicro.2016.09.003


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cc-by-nc-nd (c) Elsevier, 2016
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Elsevier, 2016