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dc.contributor.authorPereira, Tania
dc.contributor.authorVilaprinyo Terré, Ester
dc.contributor.authorBellí i Martínez, Gemma
dc.contributor.authorHerrero Perpiñán, Enrique
dc.contributor.authorSalvadó López, Baldiri
dc.contributor.authorSorribas Tello, Albert
dc.contributor.authorAltés, Gisela
dc.contributor.authorAlves, Rui
dc.date.accessioned2018-03-14T09:20:04Z
dc.date.available2018-03-14T09:20:04Z
dc.date.issued2018
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/10459.1/62832
dc.description.abstractMicroorganisms evolved adaptive responses to survive stressful challenges in ever-changing environments. Understanding the relationships between the physiological/metabolic adjustments allowing cellular stress adaptation and gene expression changes being used by organisms to achieve such adjustments may significantly impact our ability to understand and/or guide evolution. Here, we studied those relationships during adaptation to various stress challenges in Saccharomyces cerevisiae, focusing on heat stress responses. We combined dozens of independent experiments measuring whole-genome gene expression changes during stress responses with a simplified kinetic model of central metabolism. We identified alternative quantitative ranges for a set of physiological variables in the model (production of ATP, trehalose, NADH, etc.) that are specific for adaptation to either heat stress or desiccation/rehydration. Our approach is scalable to other adaptive responses and could assist in developing biotechnological applications to manipulate cells for medical, biotechnological, or synthetic biology purposes.ca_ES
dc.description.sponsorshipThis project has received funding from the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration (609396). This work was partially funded by grants from the Spanish MINECO (BFU2008- 0196 and BFU2010-17704) and Generalitat de Catalunya (2009SGR809) and bridge grants from the Dean for Research (2014, 2017) and the Departament de Ciències Mèdiques Bàsiques (2014) of the University of Lleida.ca_ES
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relationMICINN/PN2008-2011/BFU2008-0196
dc.relationMICINN/PN2008-2011/BFU2010-17704
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.celrep.2018.02.020ca_ES
dc.relation.ispartofCell Reports, 2018, vol. 22, núm. 9, p. 2421-2430ca_ES
dc.rightscc-by-nc-nd (c) Pereira et al., 2018ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleQuantitative operating principles of yeast metabolism during adaptation to heat stressca_ES
dc.typearticleca_ES
dc.identifier.idgrec026783
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2018.02.020
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/609396


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cc-by-nc-nd (c) Pereira et al., 2018
Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Pereira et al., 2018