Statins do not increase markers of cerebral angiopathies in patients with cardioembolic stroke

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2018
Author
Martí Fàbregas, Joan
Medrano-Martorell, Santiago
Merino, Elisa
Prats Sánchez, Luis
Marín, Rebeca
Delgado Mederos, Raquel
Camps Renom, Pol
Martínez Domeño, Alejandro
Gómez Choco, Manuel
Lara, Lidia
Casado-Naranjo, Ignacio
Cánovas, David
Torres, Maria José
Freijo, María del Mar
Calleja, Ana
Bravo, Yolanda
Cocho, Dolores
Rodríguez-Campello, Ana
Zandio, Beatriz
Fuentes, Blanca
Felipe, Alicia de
Llull, Laura
Maestre, José
Hernández, María
Garcés, Moisés
Arce-Borda, Ana Maria de
Palomeras, Ernest
Rodríguez-Yáñez, Manuel
Díaz-Maroto, Inma
Serrano, Marta
Fernández-Domínguez, Jéssica
Sanahuja Montesinos, Jordi
Purroy Garcia, Francisco
Zedde, Marialuisa
Delgado-Mengual, Jordi
Gich, Ignasi
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Martí Fàbregas, Joan; Medrano-Martorell, Santiago; Merino, Elisa; Prats Sánchez, Luis; Marín, Rebeca; Delgado Mederos, Raquel; ... Gich, Ignasi. (2018) . Statins do not increase markers of cerebral angiopathies in patients with cardioembolic stroke. Scientific Reports, 2018, vol. 8, núm. 1492, p. 1-8. https://doi.org/10.1038/s41598-018-20055-3.
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Abstract
We investigated whether pre-treatment with statins is associated with surrogate markers of amyloid and hypertensive angiopathies in patients who need to start long-term oral anticoagulation therapy. A prospective multicenter study of patients naive for oral anticoagulants, who had an acute cardioembolic stroke. MRI was performed at admission to evaluate microbleeds, leukoaraiosis and superficial siderosis. We collected data on the specific statin compound, the dose and the statin intensity. We performed bivariate analyses and a logistic regression to investigate variables associated with microbleeds. We studied 470 patients (age 77.5 ± 6.4 years, 43.7% were men), and 193 (41.1%) of them received prior treatment with a statin. Microbleeds were detected in 140 (29.8%), leukoaraiosis in 388 (82.5%) and superficial siderosis in 20 (4.3%) patients. The presence of microbleeds, leukoaraiosis or superficial siderosis was not related to pre-treatment with statins. Microbleeds were more frequent in patients with prior intracerebral hemorrhage (OR 9.7, 95% CI 1.06–90.9) and in those pre-treated antiplatelets (OR 1.66, 95% CI 1.09–2.53). Prior treatment with statins was not associated with markers of bleeding-prone cerebral angiopathies in patients with cardioembolic stroke. Therefore, previous statin treatment should not influence the decision to initiate or withhold oral anticoagulation if these neuroimaging markers are detected.
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http://hdl.handle.net/10459.1/62672
DOI
https://doi.org/10.1038/s41598-018-20055-3
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Scientific Reports, 2018, vol. 8, núm. 1492, p. 1-8
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Except where otherwise noted, this item's license is described as cc-by (c) Martí et al., 2018