Show simple item record

dc.contributor.authorZhu, Changfu
dc.contributor.authorFarré Martinez, Gemma
dc.contributor.authorZanga, Daniela
dc.contributor.authorLloveras Vilamanyà, Jaume
dc.contributor.authorMichelena Bárcena, Antonio
dc.contributor.authorFerrio Díaz, Juan Pedro
dc.contributor.authorVoltas Velasco, Jordi
dc.contributor.authorSlafer, Gustavo A.
dc.contributor.authorSavin, Roxana
dc.contributor.authorAlbajes Garcia, Ramon
dc.contributor.authorEizaguirre Altuna, Matilde
dc.contributor.authorLópez Alonso, Carmen
dc.contributor.authorCantero-Martínez, Carlos
dc.contributor.authorDíaz Gómez, Joana
dc.contributor.authorNogareda, Carmina
dc.contributor.authorMoreno Martínez, José Antonio
dc.contributor.authorAngulo Asensio, Eduardo
dc.contributor.authorEstany Illa, Joan
dc.contributor.authorPena i Subirà, Ramona Natacha
dc.contributor.authorTor i Naudí, Marc
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorEritja Sánchez, Núria
dc.contributor.authorArjó Pont, Gemma
dc.contributor.authorSerrano Casasola, José Carlos Enrique
dc.contributor.authorMatias-Guiu, Xavier
dc.contributor.authorTwyman, Richard M.
dc.contributor.authorSandmann, Gerhard
dc.contributor.authorCapell Capell, Teresa
dc.contributor.authorChristou, Paul
dc.date.accessioned2018-01-23T13:12:21Z
dc.date.available2018-06-03T22:24:48Z
dc.date.issued2017-06-01
dc.identifier.issn1568-7767
dc.identifier.urihttp://hdl.handle.net/10459.1/62539
dc.description.abstractCarolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel combinatorial transformation method, followed by rigorous testing for transgene expression and the accumulation of different carotenoid molecules. Carolight® was envisaged as a way to improve the nutritional health of human populations that cannot access a diverse diet, but this ultimate humanitarian application can only be achieved after extensive testing for safety, agronomic performance and nutritional sufficiency. In this article, we chart the history of Carolight® maize focusing on its development, extensive field testing for agronomic performance and resistance to pests and pathogens, and feeding trials to analyze its impact on farm animals (and their meat/dairy products) as well as animal models of human diseases. We also describe more advanced versions of Carolight® endowed with pest-resistance traits, and other carotenoid-enhanced maize varieties originating from the same series of initial transformation experiments. Finally we discuss the further steps required before Carolight® can fulfil its humanitarian objectives, including the intellectual property and regulatory constraints that lie in its path.
dc.description.sponsorshipEuropean Research Council Advanced Grant (BIOFORCE) and Proof of Concept Grant (Multinutrient Maize) to PC; Spanish Ministry of Economy and Competitiveness (AGL2014-53970-C2-1-R, AGL2015-65846-R, BIO2014-54426-P and BIO2014-54441-P); RecerCaixa project PC084082; Catalan Autonomous Community 2014 SGR 1296 Agricultural Biotechnology Research Group and Agrotecnio Research Center. JDG thanks the UdL for a Ph.D. fellowship.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Verlag
dc.relationMINECO/PN2013-2016/AGL2014-53970-C2-1-R
dc.relationMINECO/PN2013-2016/AGL2015-65846-R
dc.relationMINECO/PN2013-2016/BIO2014-54441-P
dc.relationMINECO/PN2013-2016/BIO2014-54426-P
dc.relation.isformatofhttps://doi.org/10.1007/s11101-017-9506-4
dc.relation.ispartofPhytochemistry Reviews, 2017, p. 1-15
dc.rights(c) Springer Science+Business Media, 2017
dc.subjectMaize
dc.subjectCarotenoid
dc.subjectPoultry production
dc.subjectEgg production
dc.subjectTrout feeding
dc.titleHigh-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2018-01-23T13:12:22Z
dc.identifier.idgrec027810
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.1007/s11101-017-9506-4
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/232933


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record