High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition
Data de publicació2017-06-01
Díaz Gómez, Joana
Moreno Martínez, José Antonio
Arjó Pont, Gemma
Twyman, Richard M.
MetadadesMostra el registre d'unitat complet
Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel combinatorial transformation method, followed by rigorous testing for transgene
expression and the accumulation of different carotenoid molecules. Carolight® was envisaged as a way to improve the nutritional health of human populations that cannot access a diverse diet, but this ultimate humanitarian application can only be achieved after extensive testing for safety, agronomic performance and nutritional sufficiency. In this article, we chart the history of Carolight® maize focusing on its development, extensive field testing for agronomic performance and resistance to pests and pathogens, and feeding trials to analyze its impact on farm animals (and their meat/dairy products) as well as animal models of human diseases. We also describe more advanced versions of Carolight® endowed with pest-resistance traits, and other carotenoid-enhanced maize varieties originating from the same series of initial transformation experiments. Finally we discuss the further steps required before Carolight® can fulfil its humanitarian objectives, including the intellectual property and regulatory constraints that lie in its path.
És part dePhytochemistry Reviews, 2017, p. 1-15
- Articles publicats (Grup de Recerca en Producció Forestal) 
- Publicacions de projectes finançats per la Unió Europea 
- Publicacions de projectes de recerca del Plan Nacional 
- Articles publicats (Medicina Experimental) 
- Articles publicats (Agrotecnio Center) 
- Articles publicats (Ciència Animal) 
- Articles publicats (Tecnologia dels Aliments) 
- Articles publicats (Producció Vegetal i Ciència Forestal) 
Mostrant elements relacionats per títol, autor i matèria.
Provitamin A carotenoids from an engineered high-carotenoid maize are bioavailable and zeaxanthin does not compromise β-carotene absorption in poultry Díaz Gómez, Joana; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Sandmann, Gerhard; Zhu, Changfu; Capell Capell, Teresa; Nogareda, Carmina (Springer International Publishing, 2017)High-carotenoid (HC) maize, a biofortified staple crop which accumulates β-carotene, β-cryptoxanthin, lutein and zeaxanthin, was used as a feed component in a chicken feeding trial to assess the bioavailability of provitamin ...
Díaz Gómez, Joana; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Sandmann, Gerhard; Zhu, Changfu; Ramos Girona, Antonio J.; Capell Capell, Teresa; Christou, Paul; Nogareda, Carmina (Elsevier B.V., 2017-06-12)Skin color in poultry is achieved by the addition of natural or synthetic pigments to feed. Crops used routinely in feed formulations offer an alternative cost-effective strategy to replace color additives if they are ...
Díaz Gómez, Joana; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Sandmann, Gerhard; Portero Otín, Manuel; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul; Nogareda, Carmina (Virginia Polytechnic Institute and State University, 2015-05-01)Vitamin A deficiency (VAD) is one of the most important micronutrient deficiencies globally. It is prevalent throughout the world, but it is particularly severe in Africa and South-East Asia. The main underlying cause of ...