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dc.contributor.authorRamírez-Morros, Anna
dc.contributor.authorGranado Casas, Minerva
dc.contributor.authorAlcubierre Calvo, Núria
dc.contributor.authorMartínez Alonso, Montserrat
dc.contributor.authorReal, Jordi
dc.contributor.authorCastelblanco Echavarría, Esmeralda
dc.contributor.authorEsquerda, Aureli
dc.contributor.authorCao, Gonzalo
dc.contributor.authorRubinat, Esther
dc.contributor.authorHernández, Marta
dc.contributor.authorAlonso, Núria
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorMauricio Puente, Dídac
dc.description.abstractAims. To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease. Methods. We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA. A total of 303 subjects with T2DM were included. Clinical variables and carotid ultrasound imaging were obtained. Results. We found no association of 25OHD with the presence of SCA. However, calcium phosphate (CaP; mg2/dL2) product was positively associated with the presence of carotid plaques (ORadj = 1.078; 95% CI: 1.017–1.142). An inverse association was observed between higher levels of 25OHD (≥30 ng/mL versus <20 ng/mL concentrations) and common carotid intima-media thickness (cIMT; mm) (βadj ± SE = −0.055 ± 0.024). We conclude that the CaP product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with T2DM.ca_ES
dc.description.sponsorshipThis study was supported by Grants PS09/01035 and PI15/ 00625 from Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Spain. CIBERDEM is an initiative from Instituto de Salud Carlos III (Plan Nacional de I+D+I and Fondo Europeo de Desarrollo Regional). Minerva Granado-Casas holds a predoctoral fellowship from Ministerio de Educación, Cultura y Deporte, FPU15/03005.ca_ES
dc.publisherHindawi Publishing Corporationca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofJournal of Diabetes Research, 2017, vol. 2017, id. 3498368ca_ES
dc.rightscc-by (c) Ramírez-Morros et al., 2017ca_ES
dc.titleCalcium phosphate product is associated with subclinical carotid atherosclerosis in type 2 diabetesca_ES

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cc-by (c) Ramírez-Morros et al., 2017
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