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dc.contributor.authorCabezón Ponsoda, Óscar
dc.contributor.authorMuñoz González, Sara
dc.contributor.authorColom-Cadena, Andreu
dc.contributor.authorRosell, Rosa
dc.contributor.authorLavín González, Santiago
dc.contributor.authorMarco, Ignasi
dc.contributor.authorFraile Sauce, Lorenzo José
dc.contributor.authorMartínez de la Riva, Paloma
dc.contributor.authorRodríguez, Fernando
dc.contributor.authorDomínguez, Javier
dc.contributor.authorGanges, Llilianne
dc.date.accessioned2017-10-17T08:47:18Z
dc.date.available2017-10-17T08:47:18Z
dc.date.issued2017
dc.identifier.issn1746-6148
dc.identifier.urihttp://hdl.handle.net/10459.1/60302
dc.description.abstractRecently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. These animals also showed a type I interferon blockade in the absence of clinical signs. In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV). The wild boars were divided in two groups and were infected with ASFV. Group A comprised boars who were CSFV PI in a subclinical form and Group B comprised pestivirus-free wild boars. Some relevant parameters related to CSFV replication and the immune response of CSFV PI animals were studied. Additionally, serum soluble factors such as IFN-α, TNF-α, IL-6, IL-10, IFN-γ and sCD163 were analysed before and after ASFV infection to assess their role in disease progression.ca_ES
dc.description.sponsorshipThis research was supported by grants AGL2013–48998 and AGL2015–66907 from the Spanish government. S.M and A.C hadca_ES
dc.language.isoengca_ES
dc.publisherBioMed Centralca_ES
dc.relationMINECO/PN2013-2016/AGL2013-48998
dc.relationMINECO/PN2013-2016/AGL2015-66907
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1186/s12917-017-1150-0ca_ES
dc.relation.ispartofBMC Veterinary Research, 2017, vol. 13, p. 227ca_ES
dc.rightscc-by (c) Cabezón et al., 2017ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCSFVca_ES
dc.subjectCSF postnatal persistent infectionca_ES
dc.subjectSubclinical CSFca_ES
dc.subjectASFVca_ES
dc.titleAfrican swine fever virus infection in Classical swine fever subclinically infected wild boarsca_ES
dc.typearticleca_ES
dc.identifier.idgrec025865
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1186/s12917-017-1150-0


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cc-by (c) Cabezón et al., 2017
Except where otherwise noted, this item's license is described as cc-by (c) Cabezón et al., 2017