African swine fever virus infection in Classical swine fever subclinically infected wild boars

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2017
Author
Cabezón Ponsoda, Óscar
Muñoz González, Sara
Colom-Cadena, Andreu
Rosell, Rosa
Lavín, Santiago
Marco, Ignasi
Fraile Sauce, Lorenzo José
Martínez de la Riva, Paloma
Rodríguez, Fernando
Domínguez, Javier
Ganges, Llilianne
Suggested citation
Cabezón Ponsoda, Óscar; Muñoz González, Sara; Colom-Cadena, Andreu; Rosell, Rosa; Lavín, Santiago; Marco, Ignasi; ... Ganges, Llilianne. (2017) . African swine fever virus infection in Classical swine fever subclinically infected wild boars. BMC Veterinary Research, 2017, vol. 13, p. 227. https://doi.org/10.1186/s12917-017-1150-0.
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Abstract
Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. These animals also showed a type I interferon
blockade in the absence of clinical signs. In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV). The wild boars were divided in two groups and were infected with ASFV. Group A comprised boars who were CSFV PI in a subclinical form and Group B comprised pestivirus-free wild boars. Some relevant parameters related to CSFV replication and the immune response of CSFV PI animals were studied. Additionally, serum soluble factors such as IFN-α, TNF-α, IL-6, IL-10, IFN-γ and sCD163 were analysed before and after ASFV infection to assess their role in disease progression.
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http://hdl.handle.net/10459.1/60302
DOI
https://doi.org/10.1186/s12917-017-1150-0
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BMC Veterinary Research, 2017, vol. 13, p. 227
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Except where otherwise noted, this item's license is described as cc-by (c) Cabezón et al., 2017