Traditionally, museums spaces have tended to be located in the central areas of cities, thereby reinforcing existing dynamics and limiting their potential impact on more peripheral areas. The present study examines the locations chosen for museums that have been opened in three European cities: Barcelona, Paris and Turin, between the years 2000 and 2013. It shows how the locating of museums and galleries has not been homogeneous and how each potential location has its strengths and weaknesses. This is particularly evident when we consider such factors as the environmental impact of museums and how they influence the commercial offer, image and attractiveness of their host city. This paper identifies and examines the different types of impact that museum location strategies have on urban areas.