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dc.contributor.authorPérez-Holanda Fernández, Sergio
dc.contributor.authorRodrigo, L.
dc.contributor.authorViñas Salas, Joan
dc.contributor.authorPiñol Felis, Carme
dc.date.accessioned2017-07-12T08:24:59Z
dc.date.available2017-07-12T08:24:59Z
dc.date.issued2005
dc.identifier.issn1130-0108
dc.identifier.urihttp://hdl.handle.net/10459.1/60053
dc.description.abstractAims: the present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis. Material and methods: one hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supple- ment of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) re- ceived ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental ani- mals were sacrified after 25-27 weeks. Results: no significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E. Conclusions: we concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dy- namic model of tumor induction with DMH.ca_ES
dc.description.sponsorshipLos autores quieren expresar su agradecimiento a D. Manuel Santiago por su ayuda técnica en el manejo y cui- dado de los animales. Este trabajo de investigación ha sido subvencionado por la Universidad de Lleida y con una Beca de “Ayuda a la Investigación FISS Exp. no 89/0612”.ca_ES
dc.language.isoengca_ES
dc.publisherSociedad Española de Patología Digestivaca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.4321/S1130-01082005000200003ca_ES
dc.relation.ispartofRevista Española de enfermedades digestivas, 2005, vol. 97, núm. 2, p. 87-96ca_ES
dc.rights(c) Sociedad Española de Patología Digestiva, 2005ca_ES
dc.subjectAlcoholca_ES
dc.subjectCancerca_ES
dc.subjectCarcinogenesisca_ES
dc.subjectColonca_ES
dc.subjectDimethyl- hydrazineca_ES
dc.subjectEthanolca_ES
dc.subjectNeoplasmca_ES
dc.subjectTumorsca_ES
dc.titleEffect of ethanol consumption on colon cancer in an experimental modelca_ES
dc.typearticleca_ES
dc.identifier.idgrec001552
dc.type.versionpublishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.4321/S1130-01082005000200003


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