| dc.contributor.author | Pérez-Holanda Fernández, Sergio | |
| dc.contributor.author | Rodrigo, L. | |
| dc.contributor.author | Viñas Salas, Joan | |
| dc.contributor.author | Piñol Felis, Carme | |
| dc.date.accessioned | 2017-07-12T08:24:59Z | |
| dc.date.available | 2017-07-12T08:24:59Z | |
| dc.date.issued | 2005 | |
| dc.identifier.issn | 1130-0108 | |
| dc.identifier.uri | http://hdl.handle.net/10459.1/60053 | |
| dc.description.abstract | Aims: the present study was designed to examine the effect of
an ethanol supplement on experimental colon carcinogenesis.
Material and methods: one hundred and ten 10-week-old
Sprague-Dawley rats were divided into five groups: group A (20
rats) received no treatment. Group B (20 rats) received a supple-
ment of ethanol at 1.23 g/kg of body weight per day added to
their drinking water for 24 weeks. Group C (30 rats) received 18
weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body
weight from the beginning of the study. Group D (20 rats) re-
ceived ethylen-diamin-tetracetic acid (EDTA) solution only for 18
weeks. Group E (20 rats) received ethanol at the same dose as
group B plus DMH injections at the same dose as the rats in
group C from the beginning of the study. All experimental ani-
mals were sacrified after 25-27 weeks.
Results: no significant differences in the number of rats that
developed tumors, number of tumor-free animals, and number of
tumors per rat, as well as in macro-microscopic tumoral findings
were observed for animals in group C compared to animals in
group E.
Conclusions: we concluded that the addition of an ethanol
supplement does not modify colorectal carcinogenesis using a dy-
namic model of tumor induction with DMH. | ca_ES |
| dc.description.sponsorship | Los autores quieren expresar su agradecimiento a D. Manuel Santiago por su ayuda técnica en el manejo y cui- dado de los animales. Este trabajo de investigación ha sido subvencionado por la Universidad de Lleida y con una Beca de “Ayuda a la Investigación FISS Exp. no 89/0612”. | ca_ES |
| dc.language.iso | eng | ca_ES |
| dc.publisher | Sociedad Española de Patología Digestiva | ca_ES |
| dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.4321/S1130-01082005000200003 | ca_ES |
| dc.relation.ispartof | Revista Española de enfermedades digestivas, 2005, vol. 97, núm. 2, p. 87-96 | ca_ES |
| dc.rights | (c) Sociedad Española de Patología Digestiva, 2005 | ca_ES |
| dc.subject | Alcohol | ca_ES |
| dc.subject | Cancer | ca_ES |
| dc.subject | Carcinogenesis | ca_ES |
| dc.subject | Colon | ca_ES |
| dc.subject | Dimethyl- hydrazine | ca_ES |
| dc.subject | Ethanol | ca_ES |
| dc.subject | Neoplasm | ca_ES |
| dc.subject | Tumors | ca_ES |
| dc.title | Effect of ethanol consumption on colon cancer in an experimental model | ca_ES |
| dc.type | article | ca_ES |
| dc.identifier.idgrec | 001552 | |
| dc.type.version | publishedVersion | ca_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
| dc.identifier.doi | https://doi.org/10.4321/S1130-01082005000200003 | |
