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Effect of ethanol consumption on colon cancer in an experimental model

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Fecha de publicación
2005
Autor/a
Pérez-Holanda Fernández, Sergio
Rodrigo, L.
Viñas Salas, Joan
Piñol Felis, Carme
Cita recomendada
Pérez-Holanda Fernández, Sergio; Rodrigo, L.; Viñas Salas, Joan; Piñol Felis, Carme; . (2005) . Effect of ethanol consumption on colon cancer in an experimental model. Revista Española de enfermedades digestivas, 2005, vol. 97, núm. 2, p. 87-96. https://doi.org/10.4321/S1130-01082005000200003.
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Resumen
Aims: the present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis. Material and methods: one hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supple- ment of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) re- ceived ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental ani- mals were sacrified after 25-27 weeks. Results: no significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E. Conclusions: we concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dy- namic model of tumor induction with DMH.
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http://hdl.handle.net/10459.1/60053
DOI
https://doi.org/10.4321/S1130-01082005000200003
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Revista Española de enfermedades digestivas, 2005, vol. 97, núm. 2, p. 87-96
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  • Articles publicats (Medicina) [511]
  • Articles publicats (Cirurgia) [169]

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