Effect of ethanol consumption on colon cancer in an experimental model

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Data de publicació
2005Citació recomanada
Pérez-Holanda Fernández, Sergio;
Rodrigo, L.;
Viñas Salas, Joan;
Piñol Felis, Carme;
.
(2005)
.
Effect of ethanol consumption on colon cancer in an experimental model.
Revista Española de enfermedades digestivas, 2005, vol. 97, núm. 2, p. 87-96.
https://doi.org/10.4321/S1130-01082005000200003.
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Aims: the present study was designed to examine the effect of
an ethanol supplement on experimental colon carcinogenesis.
Material and methods: one hundred and ten 10-week-old
Sprague-Dawley rats were divided into five groups: group A (20
rats) received no treatment. Group B (20 rats) received a supple-
ment of ethanol at 1.23 g/kg of body weight per day added to
their drinking water for 24 weeks. Group C (30 rats) received 18
weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body
weight from the beginning of the study. Group D (20 rats) re-
ceived ethylen-diamin-tetracetic acid (EDTA) solution only for 18
weeks. Group E (20 rats) received ethanol at the same dose as
group B plus DMH injections at the same dose as the rats in
group C from the beginning of the study. All experimental ani-
mals were sacrified after 25-27 weeks.
Results: no significant differences in the number of rats that
developed tumors, number of tumor-free animals, and number of
tumors per rat, as well as in macro-microscopic tumoral findings
were observed for animals in group C compared to animals in
group E.
Conclusions: we concluded that the addition of an ethanol
supplement does not modify colorectal carcinogenesis using a dy-
namic model of tumor induction with DMH.