L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

Enviaments recents

  • Eosinophils in the Gastrointestinal Tract: Key Contributors to Neuro-Immune Crosstalk and Potential Implications in Disorders of Brain-Gut Interaction 

    Salvo Romero, Eloísa; Rodiño Janeiro, Bruno K.; Albert Bayo, Mercé; Lobo, Beatriz; Santos, Javier; Farré, Albert; Martínez Martínez, Cristina; Vicario, María (MDPI, 2022)
    Eosinophils are innate immune granulocytes actively involved in defensive responses and in local and systemic inflammatory processes. Beyond these effector roles, eosinophils are fundamental to maintaining homeostasis in ...
  • Microbiota alterations in proline metabolism impact depression 

    Mayneris Perxachs, Jordi; Castells Nobau, Anna; Arnoriaga Rodríguez, María; Martin, Miquel; de la Vega Correa, Lisset; Zapata, Cristina; Burokas, Aurelijus; Blasco Solà, Gerard; Coll, Claudia; Escrichs, Anira; Biarnés, Carles; Moreno Navarrete, José María; Puig, Josep; Garre Olmo, Josep; Ramos, Rafel; Pedraza, Salvador; Brugada, Ramon; Vilanova, Joan Carles; Serena, Joaquín; Gich, Jordi; Ramió Torrentà, Lluís; Pérez Brocal, Vicente; Moya, Andrés; Pamplona Gras, Reinald; Sol, Joaquim; Jové Font, Mariona; Ricart, Wifredo; Portero Otín, Manuel; Deco, Gustavo; Maldonado, Rafael; Fernández Real, José Manuel (Elsevier, 2022)
    The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not ad- dressing ...
  • Avances hacia el cribado personalizado del cáncer de mama: el papel de la Atención Primaria 

    Pons Rodríguez, Anna; Marzo Castillejo, Mercè; Cruz Esteve, María Inés; Galindo Ortego, Gisela; Hernández Leal, Maria José; Rué i Monné, Montserrat (Elsevier, 2022)
    El cáncer de mama es la primera causa de muerte en el mundo entre las mujeres. El Sistema Nacional de Salud (SNS) introdujo el cribado poblacional de cáncer de mama en 1990. Como en la mayoría de los programas europeos, ...
  • Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: A development and validation study 

    Reijnen, Casper; Gogou, Evangelia; Visser, Nicole C. M.; Engerud, Hilde; Ramjith, Jordache; van der Putten, Louis J. M.; van de Vijver, Koen; Santacana, Maria; Bronsert, Peter; Bulten, Johan; Hirschfeld, Marc; Colas, Eva; Gil-Moreno, Antonio; Reques, Armando; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, Marketa; Hausnerova, Jitka; van der Wurff, Anneke A. M.; Matias-Guiu, Xavier; Amant, Frederic; Massuger, Leon F. A. G.; Snijders, Marc P. L .M.; Küsters-Vandevelde, Heidi V. N.; Lucas, Peter J. F.; Pijnenborg, Johanna M. A. (Public Library of Science, 2020-05)
    Background Bayesian networks (BNs) are machine-learning–based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical ...
  • A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe 

    Lazarus, Jeffrey V.; Ekstedt, Mattias; Marchesini, Giulio; Mullen, Jillian; Novak, Katja; Pericàs, Juan M.; Roel, Elena; Romero-Gómez, Manuel; Ratziu, Vlad; Tacke, Frank; Cortez-Pinto, Helena; Anstee, Quentin M.; EASL International Liver Foundation NAFLD Policy Review Collaborators (Elsevier, 2020-01)
    Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and has become an important field of biomedical inquiry. We aimed to determine whether European countries have ...
  • A Contemporary Picture of Enterococcal Endocarditis 

    Pericàs, Juan M.; Llopis Pérez, Jaime; Muñoz, Patricia; Gálvez Acebal, Juan; Kestler, Martha; Valerio, Maricela; Hernández Meneses, Marta; Goneaga, Miguel A.; Cobo Belaustegui, Manuel; Montejo, Miguel; Ojeda Burgos, Guillermo; Sousa Regueiro, M. Dolores; Alarcón, Aristides de; Ramos Martínez, Antonio; Miró Meda, José M.; GAMES Investigators (Elsevier, 2020-02)
    Background Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking. Objectives The purpose of this study was to describe the characteristics and ...
  • Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes 

    Cerdán Santacruz, Carlos; Codina Corrons, Laia; Merichal Resina, Mireia; Milla Collado, Lucía; Trujillano Cabello, Javier; Tarragona Foradada, Jordi; Mestres Petit, Núria; Sierra Grañón, Enrique; Olsina Kissler, Jorge Juan (Shiraz University of Medical Sciences, 2021)
    BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using ...
  • Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective 

    Bauer, Kylynda C.; Littlejohn, Paula T.; Ayala Jové, Ma. Victoria (Maria Victoria); Creus Cuadros, Anna; Finlay, Barton Brett (AGA Institute; Elsevier, 2022)
    Nonalcoholic fatty liver disease (NAFLD) is a chronic con dition affecting one quarter of the global population. Although primarily linked to obesity and metabolic syn drome, undernutrition and the altered (dysbiotic) gut ...
  • The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology 

    Jové Font, Mariona; Mota Martorell, Natàlia; Torres Cabestany, Pascual; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (MDPI, 2021)
    Current shreds of evidence point to the entorhinal cortex (EC) as the origin of the Alzheimer’s disease (AD) pathology in the cerebrum. Compared with other cortical areas, the neurons from this brain region possess an ...
  • Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment 

    Rossi, Chiara; Fernàndez, Anna; Torres Cabestany, Pascual; Ramírez Núñez, Omar; Granado-Serrano, Ana Belén; Fontdevila, Laia; Povedano, Mònica; Pamplona Gras, Reinald; Ferrer, Isidre; Portero Otín, Manuel (MDPI, 2021)
    Previous evidence links the formation of extranuclear inclusions of transcription factors, such as ERK, Jun, TDP-43, and REST, with oxidative, endoplasmic-reticulum, proteasomal, and osmotic stress. To further characterize ...
  • Redox proteomic profiling of neuroketal-adducted proteins in human brain: regional vulnerability at middle age increases in the elderly 

    Domínguez, Mayelín; de Oliveira, Eliandre; Odena, María Antonia; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (2016)
    Protein lipoxidation was assessed in the parietal cortex (PC), frontal cortex (FC), and cingulate gyrus (CG) in middle-aged and old-aged individuals with no clinical manifestations of cognitive impairment, in order to ...
  • Molecular and structural antioxidant defenses against oxidative stressin animals 

    Pamplona Gras, Reinald; Costantini, David (American Physiological Society, 2011)
    In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural ...
  • Proteins in human brain cortex are modified by oxidation, glycoxidation and lipoxidation: effects of Alzheimer's disease and identification of lipoxidation targets. 

    Pamplona Gras, Reinald; Dalfó, Esther; Ayala Jové, Ma. Victoria (Maria Victoria); Bellmunt, Maria Josep; Prat Corominas, Joan; Ferrer, Isidre; Portero Otín, Manuel (American Society for Biochemistry and Molecular Biology; Elsevier, 2005)
    Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the amount of structurally characterized probes ...
  • Melanoma transplants in “green” mice: Fluorescent cells in tumors are not equivalent to host-derived cells 

    García-Olmo, Dolores C.; Picazo, María G.; García-Olmo, Damián (Elsevier, 2018)
    Background: To examine the usefulness of green fluorescent protein (GFP) mice for studying the interactions between normal cells and tumor cells in a host, we used a melanoma model in such “green” mice [C57BL/6-Tg(CAG-EGFP)1Osb ...
  • Diálisis peritoneal incremental: resultados clínicos y preservación de la función renal residual 

    Borràs, Mercè; Chacón, Andrea; Cerdá Vilaplana, Carla; Usón Nuño, Ana; Fernández i Giráldez, Elvira (Sociedad Española de Nefrología; Elsevier, 2016)
    Introducción: En los últimos años el inicio de diálisis peritoneal (DP) con 3 recambios se ha convertido en una práctica habitual, aunque se dispone de pocos resultados clínicos publicados. Objetivo: Descripción de la ...
  • Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals 

    Pamplona Gras, Reinald; Portero Otín, Manuel; Riba, David; Ruiz, Cristina; Prat Corominas, Joan; Bellmunt, Maria Josep; Barja, Gustavo (Elsevier, 1998)
    The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. ...
  • Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness 

    Cambray Carner, Serafí; Ibarz Escuer, Mercedes; Bermúdez López, Marcelino; Marti Antonio, Manuel; Bozić Stanojević, Milica; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (MDPI, 2020)
    Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with ...
  • Study design of Heart failure Events reduction withRemote Monitoring and eHealth Support (HERMeS) 

    Yun, Sergi; Enjuanes, Cristina; Calero, Esther; Hidalgo, Encarnación; Cobo, Marta; Llàcer, Pau; García Pinilla, José Manuel; González Franco, Álvaro; Núñez, Julio; Morales Rull, José Luis; Beltrán, Paola; Delso, Cristina; Freixa Pamias, Román; Moliner, Pedro; Corbella, Xavier; Comín Colet, Josep (Wiley Open Access, 2020)
    Aims. The role of non-invasive telemedicine (TM) combining telemonitoring and teleintervention by videoconference (VC) in patients recently admitted due to heart failure (HF) (‘vulnerable phase’ HF patients) is not well ...
  • Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation 

    Sarlabous Uranga, Leonardo; Aquino Esperanza, Jose; Magrans, Rudys; de Haro, Candelaria; López-Aguilar, Josefina; Subirà, Carles; Batlle, Montserrat; Rué i Monné, Montserrat; Gomà Fernández, Gemma; Ochagavía, Ana; Fernández, Rafael; Blanch, Lluís (Scientific Reports, 2020)
    Patient-ventilator asynchronies can be detected by close monitoring of ventilator screens by clinicians or through automated algorithms. However, detecting complex patient-ventilator interactions (CP-VI), consisting of ...
  • Multidisciplinary virtual management of pulmonary nodules 

    Polanco, Dinora; González, Jessica; Gracia-Lavedan, Esther; Pinilla, Lucía; Plana, R.; Molina, M.; Pardina Solano, Marina Asunción; Barbé Illa, Ferran (Elsevier; Sociedade Portuguesa de Pneumologia, 2022)
    Introduction and objectives: Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the ...

Mostra'n més