Browsing Articles publicats (IRBLleida) by Subject "Unió neuromuscular"

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Chronic treatment with the AMPA agonist AICAR prevents skeletal muscle pathology but fails to improve clinical outcome in a mouse model of severe spinal muscular atrophy

Cerveró Cebrià, Clàudia; Montull, Neus; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Springer Verlag, 2016)

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (MN) loss and skeletal muscle paralysis. Currently there is no effective treatment other than supportive ...