Browsing Articles publicats (IRBLleida) by Subject "Glioblastoma"
Now showing items 1-6 of 6
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Antitumor Effects of Ral-GTPases Downregulation in Glioblastoma.
(MDPI, 2022-07-29)Glioblastoma (GBM) is the most common tumor in the central nervous system in adults. This neoplasia shows a high capacity of growth and spreading to the surrounding brain tissue, hindering its complete surgical resection. ... -
Cytoplasmic Cyclin D1 regulates glioblastoma dissemination
(Wiley, 2019)Glioblastoma (GBM) is a highly invasive brain neoplasia with an elevated recurrence rate after surgical resection. The CyclinD1 (Ccnd1)/Cdk4-RB1 axis is frequently altered in GBM, leading to over-proliferation by RB1 ... -
FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27
(MDPI, 2020-04-27)Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor ... -
Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers
(Taylor & Francis, 2018-01-09)WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling ... -
T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma
(American Association for Cancer Research, 2019)T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as ... -
Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling
(Elsevier, 2022-04-04)Mibefradil and NNC-55-0396, tetralol derivatives with a proven ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth ...