Now showing items 1-9 of 9

    • Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study 

      Visser, Nicole C.M.; van der Putten, Louis J. M.; van Egerschot, Alex; van de Vijver, Koen; Santacana Espasa, Maria; Bronsert, Peter; Hirschfeld, Marc; Colás, Eva; Colás, Eva; Gil-Moreno, Antonio; Garcia, Angel; Mancebo, Gemma; Alameda, Fransesc; Krakstad, Camilla; Tangen, Ingvild L.; Huvila, Jutta; Schrauwen, Stefanie; Koskas, Martin; Walker, Francine; Weinberger, Vit; Minar, Lubos; Hausnerova, Jitka; Snijders, Marc P. L. M.; van den Berg-van Erp, Saskia; Matias-Guiu, Xavier; Trovik, Jone; Amant, Frederic; Massuger, Leon F. A. G.; Bulten, Johan; Pijnenborg, Johanna M. A. (Elsevier, 2019)
      Discrimination between low- and high-grade endometrial carcinomas (ECs) is clinically relevant but can be challenging for pathologists, with moderate interobserver agreement. Insulin-like growth factor-II mRNA-binding ...
    • ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status 

      Barés Junqué, Gisel; Beà Tàrrega, Aida; Hernández, Luís; Navaridas Fernández de Bobadilla, Raúl; Felip, Isidre; Megino-Luque, Cristina; Blasco Angulo, Natividad; Nadeu, Ferran; Campo, Elías; Llovera i Tomàs, Marta; Dolcet Roca, Xavier; Sanchis, Daniel (MDPI, 2021)
      EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG ...
    • Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists 

      Malpica, Anais; Euscher, Elizabeth; Hecht, Jonathan; Ali-Fehmi, Rouba; Quick, Charles; Singh, Naveena; Horn, Lars-Christian; Alvarado-Cabrero, Isabel; Matias-Guiu, Xavier; Hirschowitz, Lynn; Duggan, Máire; Ordi, Jaume; Parkash, Vinita; Mikami, Yoshiki; Quddus, M. Ruhul; Zaino, Richard; Staebler, Annette; Zaloudek, Charles; McCluggage, W. Glenn; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
      Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients ...
    • Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer 

      Vrede, S. W.; Van Weelden, Willem Jan; Visser, N. C. M.; Bulten, Johan; van der Putten, Louis J. M.; van de Vijver, Koen; Santacana Espasa, Maria; Colàs Campàs, Laura; Gil-Moreno, Antonio; Moiola, Cristian P.; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, M.; Hausnerova, Jitka; van der Wurff, Anneke A. M.; Matias-Guiu, Xavier; Amant, Frederic; ENITEC Consortium; Snijders, Marc P. L. M.; Küsters-Vandevelde, Heidi V. N; Reijnen, Casper; Pijnenborg, Johanna M. A. (Elsevier, 2021)
      Objective Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ...
    • International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group 

      Cho, Kathleen R.; Cooper, Kumarasen; Croce, Sabrina; Djordevic, Bojana; Herrington, Simon; Howitt, Brooke; Ip, Philip; Koebel, Martin; Lax, Sigurd; Quade, Bradley; Shaw, Patricia; Vidal, August; Yemelyanova, Anna; Clarke, Blaise; Hedrick Ellenson, Lora; Longacre, Teri A; Shih, Ie-Ming; McCluggage, W. Glenn; Malpica, Anais; Oliva, Esther; Parkash, Vinita; Matias-Guiu, Xavier (Lippincott, Williams & Wilkins, 2019)
      The aim of this article is to propose guidelines and recommendations in problematic areas in pathologic reporting of endometrial carcinoma (EC) regarding special techniques and ancillary studies. An organizing committee ...
    • Molecular Basis of Tumor Heterogeneity in Endometrial Carcinosarcoma 

      Leskelä, Susanna; Pérez-Mies, Belén; Rosa-Rosa, Juan Manuel; Cristobal, Eva; Biscuola, Michele; Palacios-Berraquero, María L.; Ong, SuFey; Matias-Guiu, Xavier; Palacios, José (MDPI, 2019)
      Endometrial carcinosarcoma (ECS) represents one of the most extreme examples of tumor heterogeneity among human cancers. ECS is a clinically aggressive, high-grade, metaplastic carcinoma. At the morphological level, ...
    • Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias 

      Dosil Garcia, Maria Alba; Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Felip, Isidre; Navaridas Fernández de Bobadilla, Raúl; Gatius Calderó, Sònia; Santacana Espasa, Maria; Colás, Eva; Moiola, Cristian P.; Schoenenberger, Joan Antoni; Encinas Martín, Mario; Garí Marsol, Eloi; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Wiley, 2017-04-28)
      PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the ...
    • Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade) 

      Singh, Naveena; Hirschowitz, Lynn; Zaino, Richard; Alvarado-Cabrero, Isabel; Duggan, Máire; Ali-Fehmi, Rouba; Euscher, Elizabeth; Hecht, Jonathan; Horn, Lars-Christian; Ioffe, Olga; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mikami, Yoshiki; Ordi, Jaume; Parkash, Vinita; Quddus, M. Ruhul; Quick, Charles; Staebler, Annette; Zaloudek, Charles; Nucci, Marisa; Malpica, Anais; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
      Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The ...
    • Reproducibility of measurement of myometrial invasion in endometrial carcinoma 

      van der Putten, Louis J. M.; van de Vijver, Koen; Bartosch, Carla; Davidson, Ben; Gatius Calderó, Sònia; Matias-Guiu, Xavier; McCluggage, W. Glenn; Toledo, Gemma; van der Wurff, Anneke A. M.; Pijnenborg, Johanna M. A.; Massuger, Leon F. A. G.; Bulten, Johan (Springer Berlin Heidelberg, 2016)
      Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute ...